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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM19A3 |
| Uniprot No | Q7Z5A8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 31-169aa |
| 氨基酸序列 | ALQPPTATVLVQQGTCEVIAAHRCCNRNRIEERSQTVKCSCFSGQVAGTTRAKPSCVDDLLLAAHCARRDPRAALRLLLPQPPSSCRDGGVRWSPACRGRSVRCSRTCRDGAAAVDTKSKPPRSHDSSWGSRPGQERLD |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于FAM19A3重组蛋白的3篇参考文献示例(注：部分信息为假设性概括，实际文献可能需要根据数据库查询验证)：
1. **文献名称**：*"Recombinant FAM19A3 protein inhibits neuroinflammation via modulating microglial activation"*
**作者**：Zhang Y, et al.
**摘要**：研究通过大肠杆菌系统表达FAM19A3重组蛋白，证实其能抑制小胶质细胞炎症因子释放，可能通过TLR4/NF-κB通路减轻神经炎症反应。
2. **文献名称**：*"Expression and functional characterization of FAM19A3 as a novel chemokine-like secreted protein in cancer progression"*
**作者**：Wang L, et al.
**摘要**：利用哺乳动物细胞系成功表达并纯化FAM19A3重组蛋白，发现其通过结合CCR2受体抑制肿瘤细胞迁移，提示其潜在抗肿瘤作用。
3. **文献名称**：*"FAM19A3 recombinant protein as a biomarker for early detection of Alzheimer's disease in cerebrospinal fluid"*
**作者**：Kim S, et al.
**摘要**：开发了高纯度FAM19A3重组蛋白，并建立ELISA检测方法，发现阿尔茨海默症患者脑脊液中FAM19A3水平显著降低，可能成为诊断标志物。
**注意**：以上为模拟文献摘要，实际研究需查询PubMed、Web of Science等平台。FAM19A3相关研究较少，建议结合其家族蛋白(如FAM19A1/TAFA)的功能进行扩展检索。
FAM19A3 (Family with sequence similarity 19 member A3) is a secreted protein belonging to the FAM19A family, a group of poorly characterized proteins sharing conserved structural features, including an N-terminal signal peptide and multiple cysteine-rich domains. These proteins are hypothesized to function as chemokine-like factors, potentially regulating immune responses, cellular communication, or tissue homeostasis through autocrine/paracrine signaling. FAM19A3 is encoded by the FAM19A3 gene, located on human chromosome 9q32. and is expressed in various tissues, with higher levels observed in the brain, reproductive organs, and immune-related cells.
While its precise biological role remains unclear, emerging studies suggest FAM19A3 may participate in disease-related pathways. It has been implicated in cancer progression, neuroinflammation, and neurodegenerative disorders. For example, hypermethylation of the FAM19A3 promoter has been identified as a potential biomarker for early-stage colorectal cancer. In the central nervous system, FAM19A3 is upregulated in reactive astrocytes under pathological conditions, hinting at a role in glial cell activation or neuroprotection.
Recombinant FAM19A3 protein is typically produced using mammalian expression systems (e.g., HEK293 or CHO cells) to ensure proper post-translational modifications, though bacterial systems are occasionally employed for structural studies. The purified protein enables functional investigations, including receptor binding assays, signaling pathway analysis, and in vitro cell migration studies. Current research challenges include identifying its cognate receptor(s), mapping tissue-specific functions, and clarifying its dual roles in physiological maintenance and disease contexts. As an understudied protein, FAM19A3 represents a frontier for discovering novel therapeutic targets or diagnostic markers, particularly in oncology and neurology.
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