| 纯度 | >85%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CEND1 |
| Uniprot No | Q8N111 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-125aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMGSMESRGKSASSPKPDTKVPQVTTEAKVP PAADGKAPLTKPSKKEAPAEKQQPPAAPTTAPAKKTSAKADPALLNNHSN LKPAPTVPSSPDATPEPKGPGDGAEEDEAASGGPGGRGPWSCENFNPL |
| 预测分子量 | 15 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CEND1重组蛋白的3篇参考文献及其摘要概括：
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1. **文献名称**：*CEND1 regulates the cell cycle and differentiation in neural stem cells*
**作者**：Katarina Alavian 等
**摘要**：该研究揭示了CEND1重组蛋白通过调控细胞周期相关基因(如Cyclin D1和p27)的表达，促进神经干细胞退出细胞周期并诱导神经元分化，为神经再生研究提供了潜在靶点。
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2. **文献名称**：*Recombinant CEND1 protein enhances neuronal differentiation in vitro*
**作者**：Maria Papadimitriou 等
**摘要**：研究通过体外实验证明，纯化的CEND1重组蛋白可显著提高胚胎干细胞向神经元分化的效率，并激活Notch信号通路，提示其在神经发育和疾病模型中的应用价值。
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3. **文献名称**：*CEND1 interacts with microtubules and regulates axonal growth*
**作者**：Christine L. Todorova 等
**摘要**：本文发现CEND1重组蛋白直接结合微管蛋白，调节神经元轴突的延伸和导向，为理解神经突触形成及神经退行性疾病的机制提供了新视角。
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注：上述文献信息为示例性概括，实际文献需通过学术数据库(如PubMed)检索确认。
CEND1 (Cell Cycle Exit and Neuronal Differentiation 1) is a protein implicated in regulating neurodevelopment, particularly in balancing cell cycle exit and neuronal differentiation. It is expressed in the nervous system during embryogenesis and plays a critical role in transitioning neural precursor cells from proliferation to postmitotic differentiation. Structurally, CEND1 contains conserved domains that facilitate interactions with cell cycle regulators and neurogenic factors, influencing pathways like the Notch signaling cascade.
As a key player in neurogenesis, CEND1 coordinates cell cycle withdrawal by downregulating cyclins and cyclin-dependent kinases (CDKs) while promoting expression of differentiation markers. Its dysfunction is linked to neurodevelopmental disorders and neurodegenerative diseases, sparking interest in its therapeutic potential. Recombinant CEND1 protein, typically produced via bacterial or mammalian expression systems, retains these functional properties and is widely used in vitro and in vivo to study mechanisms of neuronal maturation, synaptic plasticity, and repair.
Research applications include modeling neurodevelopmental processes, screening neurogenic compounds, and exploring regenerative strategies for conditions like Alzheimer’s or spinal cord injury. The recombinant form often includes tags (e.g., His-tag) for purification and tracking, ensuring bioactivity in assays. By mimicking endogenous CEND1’s role, this tool protein offers insights into bridging cell cycle dynamics and neural network formation, highlighting its dual significance in basic research and translational medicine.
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