关键信息
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基因名
TP73
- 应用
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别名
p53 like transcription factor; p53 related Protein; p53-like transcription factor; p53-related Protein; p73; P73_HUMAN; TP73; Tumor Protein p73
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15350
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表达区间
1-636 aa
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氨基酸序列
MAQSTATSPD GGTTFEHLWS SLEPDSTYFD LPQSSRGNNE VVGGTDSSMD VFHLEGMTTS VMAQFNLLSS TMDQMSSRAA SASPYTPEHA ASVPTHSPYA QPSSTFDTMS PAPVIPSNTD YPGPHHFEVT FQQSSTAKSA TWTYSPLLKK LYCQIAKTCP IQIKVSTPPP PGTAIRAMPV YKKAEHVTDV VKRCPNHELG RDFNEGQSAP ASHLIRVEGN NLSQYVDDPV TGRQSVVVPY EPPQVGTEFT TILYNFMCNS SCVGGMNRRP ILIIITLEMR DGQVLGRRSF EGRICACPGR DRKADEDHYR EQQALNESSA KNGAASKRAF KQSPPAVPAL GAGVKKRRHG DEDTYYLQVR GRENFEILMK LKESLELMEL VPQPLVDSYR QQQQLLQRPS HLQPPSYGPV LSPMNKVHGG MNKLPSVNQL VGQPPPHSSA ATPNLGPVGP GMLNNHGHAV PANGEMSSSH SAQSMVSGSH CTPPPPYHAD PSLVSFLTGL GCPNCIEYFT SQGLQSIYHL QNLTIEDLGA LKIPEQYRMT IWRGLQDLKQ GHDYSTAQQL LRSSNAATIS IGGSGELQRQ RVMEAVHFRV RHTITIPNRG GPGGGPDEWA DFGFDLPDCK ARKQPIKEEF TEAEIH
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分子量
69.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
TP73, a member of the p53 family of transcription factors, plays a significant role in the regulation of cellular processes such as cell cycle progression, apoptosis, andDNA damage response. Unlike its well-studied counterparts, TP53, TP73 exhibits unique characteristics, including various isoforms due to alternative splicing, which contribute to its functional diversity. Research has indicated that TP73 can function both as a tumor suppressor and, in certain contexts, as an oncogene, depending on the specific isoform and the cellular environment. Its involvement in cancer progression, neurodegeneration, and developmental disorders has sparked interest in understanding the molecular mechanisms underlying its activity. Furthermore, TP73's potential as a therapeutic target, particularly in cancers resistant to conventional treatments, underscores the importance of investigating its structure and function. The study of recombinant TP73 proteins offers valuable tools for elucidating the protein's functional dynamics, protein-protein interactions, and regulatory networks in which it is involved. By generating and characterizing these recombinant proteins, researchers aim to harness insights into TP73's biological roles, paving the way for novel therapeutic strategies that leverage this intriguing protein's capabilities in combating disease.
