关键信息
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基因名
XRCC6BP1
- 应用
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别名
ATP23; KUB3; XRCC6BP1Mitochondrial inner membrane protease ATP23 homolog; EC 3.4.24.-; Ku70-binding Protein 3; XRCC6-binding Protein 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6H3
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表达区间
1-246 aa
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氨基酸序列
MAGAPDERRRGPAAGEQLQQQHVSCQVFPERLAQGNPQQGFFSSFFTSNQKCQLRLLKTLETNPYVKLLLDAMKHSGCAVNKDRHFSCEDCNGNVSGGFDASTSQIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFTNIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI
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分子量
52.69 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
XRCC6BP1, also known as Ku86, is a critical component of the DNA repair machinery, specifically involved in the non-homologous end joining (NHEJ) pathway. This pathway is vital for repairing double-strand breaks in DNA, which can occur due to various factors such as ionizing radiation, oxidative stress, and during normal cellular processes. Dysregulation of XRCC6BP1 has been implicated in various diseases, including cancer, where faulty repair mechanisms can lead to genomic instability and tumor progression. The study of XRCC6BP1 protein has gained significant attention as researchers aim to elucidate its role in DNA repair, cell survival, and response to genotoxic stress. Understanding the molecular functions and interactions of XRCC6BP1 can provide insights into cancer biology and potential therapeutic targets. Additionally, the exploration of XRCC6BP1 as a recombinant protein allows for the examination of its biochemical properties and interactions in a controlled environment, paving the way for advancements in targeted therapies and personalized medicine. Thus, the investigation of XRCC6BP1 serves as an important avenue in the field of molecular biology and cancer research, with potential implications for improving treatment strategies and outcomes for patients with DNA repair-related disorders.
