关键信息
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基因名
DSCR2
- 应用
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别名
PSMG1; C21LRP; DSCR2; PAC1; Proteasome assembly chaperone 1; PAC-1; Chromosome 21 leucine-rich protein; C21-LRP; Down syndrome critical region protein 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95456
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表达区间
1-288aa
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氨基酸序列
MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQLARKREVRLLRRQTKTSLEVSLLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAFCVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSESTGSLPSPFLRALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVMKLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT
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分子量
57.42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
DSCR2 (Down Syndrome Candidate Region 2) is a gene located in the Down syndrome critical region on chromosome 21, which has garnered attention due to its potential implications in developmental processes and various pathologies. Research has shown that DSCR2 plays a crucial role in regulating cellular functions, including apoptosis, cell proliferation, and stress responses, making it a candidate for further investigation in the context of Down syndrome and other diseases. The protein encoded by DSCR2 is believed to be involved in the modulation of inflammatory responses and has been linked to disorders such as Alzheimer's disease and cancer. Understanding the molecular mechanisms of DSCR2 may provide insights into the pathophysiology of these conditions. Recent studies have focused on its structural properties and functional domains, which could elucidate its role in cellular signaling pathways. Additionally, the exploration of DSCR2's interactions with other proteins and its potential as a therapeutic target is of significant interest in the quest to develop novel interventions for related diseases. Given its multifaceted roles in health and disease, the study of DSCR2 protein is pivotal in advancing our knowledge of genetic regulation and its broader implications on human health.
