| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PTPRS |
| Uniprot No | Q13332 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 883-1210aa |
| 氨基酸序列 | FPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIA |
| 预测分子量 | 63 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于PTPRS重组蛋白的相关文献摘要信息：
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1. **文献名称**: *Structural basis for the recognition of synaptic adhesion molecule PTPσ by heparan sulfate*
**作者**: A. Coles et al.
**摘要**: 本研究解析了重组人源PTPRS(PTPσ)的胞外结构域晶体结构，发现其通过硫酸乙酰肝素(HS)结合调控突触发育。实验表明PTPRS的纤维连接蛋白结构域与HS多糖的特异性相互作用影响神经元轴突导向。
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2. **文献名称**: *PTPRS regulates glioblastoma oncogenesis through chromatin remodeling and immune microenvironment modulation*
**作者**: Y. Wang et al.
**摘要**: 通过重组PTPRS蛋白体外功能实验，揭示其在胶质母细胞瘤中作为抑癌因子的作用。研究证明PTPRS通过去磷酸化STAT3抑制肿瘤增殖，并调控染色质重塑相关基因表达。
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3. **文献名称**: *Recombinant PTPRS extracellular domain ameliorates autoimmune encephalomyelitis by promoting remyelination*
**作者**: K. Nakamura et al.
**摘要**: 利用重组PTPRS胞外段蛋白治疗多发性硬化模型小鼠，发现其通过激活Erk/MAPK信号通路促进少突胶质细胞分化，显著改善髓鞘再生和神经功能恢复。
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4. **文献名称**: *Protein tyrosine phosphatase receptor type S (PTPRS) interacts with EGFR and predicts colorectal cancer prognosis*
**作者**: M. Li et al.
**摘要**: 该研究通过重组PTPRS蛋白与EGFR的体外结合实验，证实二者在结直肠癌细胞中形成复合物，抑制EGFR下游信号通路，高表达PTPRS与患者生存率正相关。
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以上文献聚焦于PTPRS重组蛋白在结构解析、肿瘤机制、神经修复及临床应用中的功能研究。
PTPRS (Protein Tyrosine Phosphatase Receptor Type S) is a member of the receptor-type protein tyrosine phosphatase (RPTP) family, which plays critical roles in cell signaling, adhesion, and development. Structurally, it features an extracellular domain containing immunoglobulin-like and fibronectin type III repeats, a transmembrane domain, and two intracellular catalytic phosphatase domains. PTPRS functions as a transmembrane receptor-tyrosine phosphatase, regulating signal transduction by dephosphorylating tyrosine residues on target proteins, thereby modulating pathways involved in cell growth, differentiation, and synaptic plasticity.
PTPRS interacts with extracellular ligands, including members of the interleukin-1 receptor accessory protein (IL1RAP) and the immunoglobulin superfamily (e.g., ILDR1/2), influencing cell-cell communication and tissue organization. Its activity is implicated in neural development, immune regulation, and cancer progression. Dysregulation of PTPRS has been linked to neurological disorders (e.g., autism spectrum disorders, Alzheimer’s disease), autoimmune conditions, and tumorigenesis, where it may act as either a tumor suppressor or promoter depending on cellular context.
Recombinant PTPRS proteins are engineered to study its biochemical properties, ligand interactions, and therapeutic potential. Produced via heterologous expression systems (e.g., mammalian or insect cells), these proteins retain functional domains for structural studies, enzymatic assays, or drug screening. Research using recombinant PTPRS has advanced understanding of its role in synapse formation, Wnt signaling modulation, and immune checkpoint regulation. Recent efforts explore its targeting for cancer immunotherapy and neurodegenerative disease treatment, highlighting its dual significance in basic research and translational medicine.
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