关键信息
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基因名
NOTCH2NL
- 应用
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别名
NOTCH2NL；N2N；NOTCH2NL；Notch homolog 2 N-terminal-like Protein A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z3S9
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表达区间
1-236aa
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氨基酸序列
MCVTYHNGTG YCKCPEGFLG EYCQHRDPCE KNRCQNGGTC VAQAMLGKAT CRCASGFTGE DCQYSTSHPC FVSRPCLNGG TCHMLSRDTY ECTCQVGFTG KECQWTDACL SHPCANGSTC TTVANQFSCK CLTGFTGQKC ETDVNECDIP GHCQHGGTCL NLPGSYQCQC LQGFTGQYCD SLYVPCAPSP CVNGGTCRQT GDFTFECNCL PETVRRGTEL WERDREVWNG KEHDEN
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
NOTCH2NL is a recently identified protein implicated in neurodevelopment, particularly in the evolution of the human brain. It is a member of the Notch gene family and has been shown to play a critical role in the regulation of neural progenitor cell proliferation and differentiation. NOTCH2NL exhibits distinct structural features that differentiate it from other Notch ligands, suggesting a unique role in signaling pathways. Studies indicate that variations in NOTCH2NL expression levels may influence cognitive abilities and may be linked to neurodevelopmental disorders. Recent research has also highlighted its potential involvement in human brain size expansion, diverging from that of non-human primates. Understanding the molecular mechanisms of NOTCH2NL's action is crucial for comprehending its function in brain development and its contribution to the evolutionary advantages observed in humans. Thus, it is of great interest to characterize NOTCH2NL recombinant proteins for functional assays, which will shed light on their biological roles and potential therapeutic applications in neurological conditions. High-quality recombinant NOTCH2NL proteins can be utilized for structural studies, binding assays, and screening for modulators that may target this pathway, ultimately aiding in the development of new strategies for treating related disorders.
