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IL-17A Rabbit mAb, unconjugated, detector(PBS Only)

  • 中文名: IL-17A抗体
货号: IPDX200842
Price: ¥2580
数量:
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经过测试的应用
偶联物Unconjugated
修饰Unmodified
反应物种Human
SwissProt IDQ16552
抗体类型Monoclonal Antibody
克隆性Monoclonal
宿主Rabbit
基因名IL17A
背景信息IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.
形式Liquid
存储缓冲液0.01M PBS, pH 7.2
储存Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

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