| 经过测试的应用 | |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 反应物种 | Human |
| SwissProt ID | Q16552 |
| 抗体类型 | Monoclonal Antibody |
| 克隆性 | Monoclonal |
| 宿主 | Rabbit |
| 基因名 | IL17A |
| 背景信息 | IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively. |
| 形式 | Liquid |
| 存储缓冲液 | 0.01M PBS, pH 7.2 |
| 储存 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
×
