| 经过测试的应用 | |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 反应物种 | Human |
| SwissProt ID | P40933 |
| 抗体类型 | Monoclonal Antibody |
| 克隆性 | Monoclonal |
| 宿主 | Rabbit |
| 基因名 | IL15 |
| 背景信息 | The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. |
| 形式 | Liquid |
| 存储缓冲液 | 0.01M PBS, pH 7.2 |
| 储存 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
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