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| 纯度 | >95%SDS-PAGE. |
| 种属 | mouse |
| 靶点 | MCP5 |
| Uniprot No | 287562 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 23-104aa |
| 氨基酸序列 | GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTILDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG |
| 预测分子量 | 9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3条关于MCP5重组蛋白的虚构参考文献示例(仅供格式参考，非真实文献)：
1. **文献名称**: "Expression and Purification of Recombinant MCP5 for Structural Studies"
**作者**: Smith A, et al.
**摘要**: 本研究成功在大肠杆菌中表达了MCP5重组蛋白，并通过亲和层析纯化获得高纯度产物。通过X射线晶体学解析了MCP5的三维结构，揭示了其与补体系统调控相关的关键功能域。
2. **文献名称**: "MCP5 as a Diagnostic Marker: Development of an ELISA-Based Assay"
**作者**: Zhang L, et al.
**摘要**: 研究团队利用重组MCP5蛋白开发了一种新型ELISA检测方法，用于快速诊断自身免疫性疾病。实验证明，MCP5在患者血清中特异性高表达，具有潜在临床诊断价值。
3. **文献名称**: "Functional Characterization of Recombinant MCP5 in Viral Pathogenesis"
**作者**: Johnson R, et al.
**摘要**: 通过哺乳动物细胞表达系统制备MCP5重组蛋白，发现其与某病毒衣壳蛋白相互作用，调控宿主免疫应答。研究为抗病毒药物靶点开发提供了新方向。
**注**：以上文献为示例，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的文献，并核对作者及摘要准确性。
**Background of MCP5 Recombinant Protein**
MCP5 (Major Capsid Protein 5) is a structural protein derived from viruses, most notably from the *Adenoviridae* family, where it plays a critical role in viral assembly and infectivity. As a key component of the viral capsid, MCP5 contributes to the formation of the icosahedral protein shell that encapsulates the viral genome, ensuring stability and facilitating host cell entry. Its conserved structural motifs and antigenic properties make it a focal point in virology and biotechnology research.
Recombinant MCP5 is produced through genetic engineering, typically by expressing the *mcp5* gene in heterologous systems such as *E. coli*, yeast, or mammalian cell cultures. This allows large-scale production of the protein with high purity, bypassing the need for native viral propagation. The recombinant form retains the functional and structural characteristics of the native protein, enabling its use in diverse applications.
In biomedical research, MCP5 recombinant protein is employed to study viral pathogenesis, host-pathogen interactions, and immune responses. It serves as an antigen in serological assays to detect antiviral antibodies, aiding in diagnostics and vaccine development. Additionally, its role in viral capsid assembly has spurred interest in engineered viral vectors for gene therapy, where modified MCP5 can improve vector stability, tissue targeting, or immune evasion.
Beyond therapeutics, MCP5 is utilized in nanotechnology and drug delivery systems due to its self-assembling properties. Researchers exploit its ability to form virus-like particles (VLPs) for encapsulating therapeutic molecules or as scaffolds for antigen presentation in novel vaccine platforms.
Overall, MCP5 recombinant protein bridges virology, immunology, and bioengineering, offering tools to advance both fundamental science and clinical innovations. Its versatility underscores its importance in addressing challenges in infectious diseases, oncology, and gene-based therapies.
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