| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZFP1 |
| Uniprot No | Q6P2D0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-352 aa |
| 活性数据 | MERDHRNPDEQARQFLILKNQTPIEERGDLFGKALNLNTDFVSLRQVPYKYDLYEKTLKYNSDLLNSNRSYAGKQTDECNEFGKALLYLKQEKTHSGVEYSEYNKSGKALSHKAAIFKHQKIKNLVQPFICTYCDKAFSFKSLLISHKRIHTGEKPYECNVCKKTFSHKANLIKHQRIHTGEKPFECPECGKAFTHQSNLIVHQRAHMEKKPYECSECGKTFAQKFELTTHQRIHTGERPYECNECAKTFFKKSNLIIHQKIHTGEKRYECSECGKSFIQNSQLIIHMRTHTGEKPYECTECGKTFSQRSTLRLHLRIHTGEKPYECSECGKAFSRKSRLSVHQRVHIGEKP |
| 分子量 | 67.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3-4条关于重组人ZFP1(Zinc Finger Protein 1)蛋白的模拟参考文献示例(文献信息为虚构，供格式参考)：
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1. **文献名称**: *Structural and Functional Analysis of Recombinant Human ZFP1 Protein*
**作者**: Chen L, et al.
**摘要**: 本研究通过原核表达系统纯化重组人ZFP1蛋白，解析其锌指结构域与DNA结合的晶体结构，揭示其通过特异性识别基因启动子区调控靶基因转录的分子机制。
2. **文献名称**: *ZFP1-Mediated Transcriptional Repression in Cellular Differentiation*
**作者**: Smith KA, et al.
**摘要**: 文章报道重组人ZFP1蛋白通过招募组蛋白去乙酰化酶(HDACs)形成复合物，抑制干细胞多能性基因(如OCT4)的表达，从而促进胚胎干细胞分化。
3. **文献名称**: *Recombinant ZFP1 as a Novel Antiviral Host Factor Against DNA Viruses*
**作者**: Wang Y, et al.
**摘要**: 实验表明重组ZFP1蛋白可靶向结合疱疹病毒基因组特定序列，抑制病毒DNA复制，并激活干扰素信号通路，提示其在抗病毒治疗中的潜在应用。
4. **文献名称**: *Interaction Between ZFP1 and p53: Implications in Tumor Suppression*
**作者**: Gupta R, et al.
**摘要**: 研究发现重组ZFP1蛋白通过直接结合p53蛋白增强其稳定性，协同调控凋亡相关基因(如BAX)的表达，进而抑制肿瘤细胞增殖。
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**注意**：以上文献为模拟示例，具体内容需通过学术数据库(如PubMed、Web of Science)检索真实文献。如需实际文献支持，可提供更具体的研究方向(如结构、功能或疾病关联)。
Zinc finger protein 1 (ZFP1), also known as ZNF745. is a member of the zinc finger protein family characterized by conserved Cys2-His2 (C2H2) zinc finger domains that mediate sequence-specific DNA binding. These domains enable ZFP1 to regulate gene expression by interacting with promoter regions or enhancers of target genes. As a transcription factor, ZFP1 is implicated in diverse cellular processes, including differentiation, apoptosis, and chromatin remodeling. Its involvement in epigenetic regulation and transcriptional repression has drawn attention in studies of cancer, neurodegenerative diseases, and developmental disorders.
Recombinant human ZFP1 protein is typically produced using expression systems like *E. coli* or mammalian cells, followed by purification to ensure functional activity. This engineered protein serves as a critical tool for elucidating ZFP1's molecular mechanisms, such as its binding motifs, interaction partners, and role in signaling pathways. Research highlights its potential in gene therapy and genome engineering, where engineered zinc finger domains are tailored to target specific DNA sequences for precise genome editing—a concept foundational to technologies like zinc finger nucleases (ZFNs). Despite its lower profile compared to CRISPR-based systems, ZFP1 remains a valuable model for studying programmable DNA-protein interactions and developing therapeutic strategies for genetic diseases.
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