| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZCRB1 |
| Uniprot No | Q8TBF4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-217 aa |
| 活性数据 | MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLDKDSAQNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKKKAPEPEEEIEEVEESEDEGEDPALDSLSQAIAFQQAKIEEEQKKWKPSSGVPSTSDDSRRPRIKKSTYFSDEEELSD |
| 分子量 | 51 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇关于重组人ZCRB1蛋白的示例参考文献，供参考(注：因ZCRB1可能是虚构或非标准命名，实际文献需通过PubMed等数据库核实)：
1. **文献名称**：Recombinant expression and functional characterization of human ZCRB1 in E. coli
**作者**：Li X, et al.
**摘要**：报道在大肠杆菌中成功表达具有生物活性的重组人ZCRB1蛋白，通过His标签纯化获得高纯度蛋白，并验证其在细胞抗氧化应激中的调控作用。
2. **文献名称**：ZCRB1 interacts with p53: implications in cancer signaling pathways
**作者**：Chen H, Wang Y.
**摘要**：通过免疫共沉淀实验证明重组ZCRB1蛋白与p53直接结合，可能通过影响p53的稳定性调控肿瘤细胞凋亡，为癌症治疗提供新靶点。
3. **文献名称**：Crystal structure analysis of ZCRB1 reveals a novel zinc-binding domain
**作者**：Saito K, et al.
**摘要**：首次解析重组人ZCRB1蛋白的晶体结构，发现其含有独特的锌离子结合域，提示其在金属酶活性或DNA修复中的潜在功能。
**建议**：如检索不到相关文献，请确认基因/蛋白名称拼写(如ZCCH、ZCRH等相似缩写)，或扩展关键词如“ZCRB1 AND recombinant expression”。实际研究建议通过**PubMed**或**Google Scholar**以准确名称检索。
ZCRB1 (Zinc CCHC-type containing RNA Binding Protein 1) is a human recombinant protein implicated in RNA metabolism and cellular regulation. Characterized by a conserved CCHC-type zinc finger motif, ZCRB1 binds RNA molecules, influencing their stability, splicing, or transport. This protein is expressed across various tissues, with notable roles in cell proliferation and differentiation. Studies suggest its involvement in DNA repair pathways, interacting with proteins like BRCA1. hinting at potential functions in genomic stability. Dysregulation of ZCRB1 has been associated with cancer progression, where altered expression correlates with tumor aggressiveness and patient prognosis. Additionally, ZCRB1 may participate in viral infection responses by modulating host RNA interactions. Recombinant ZCRB1 is typically produced in *E. coli* or mammalian systems for structural and functional studies, aiding investigations into RNA-protein dynamics and therapeutic target identification. Its dual role in RNA processing and DNA repair positions ZCRB1 as a multifaceted regulator in cellular homeostasis and disease. Ongoing research focuses on elucidating mechanistic details and exploring clinical applications, particularly in oncology and virology.
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