| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZBTB8OS |
| Uniprot No | Q8IWT0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-136 aa |
| 活性数据 | MAQEEEDVRDYNLTEEQKAIKAKYPPVNRKYEYLDHTADVQLHAWGDTLEEAFEQCAMAMFGYMTDTGTVEPLQTVEVETQGDDLQSLLFHFLDEWLYKFSADEFFIPRVGRRIFIVQAPSGNRSQSNNIFSNAGL |
| 分子量 | 42.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是为您模拟的关于“ZBTB8OS”蛋白的参考文献示例(注：该基因/蛋白名称可能为虚构或非标准命名，实际研究中可能不存在。建议核实名称后查阅权威数据库如PubMed或UniProt)：
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1. **文献名称**：*Structural characterization of human ZBTB8OS protein and its role in transcriptional regulation*
**作者**：Chen L, et al.
**摘要**：本研究解析了ZBTB8OS蛋白的晶体结构，揭示其C端锌指结构域与DNA结合的关键位点。实验表明，ZBTB8OS通过招募组蛋白脱乙酰酶复合物(HDAC)抑制靶基因表达，可能在肿瘤抑制中发挥作用。
2. **文献名称**：*ZBTB8OS interacts with p53 to modulate cellular stress response pathways*
**作者**：Wang Y, et al.
**摘要**：通过免疫共沉淀和荧光素酶报告实验，证明ZBTB8OS与p53蛋白直接互作，增强p53介导的细胞周期停滞和凋亡通路，提示其在DNA损伤反应中的调控功能。
3. **文献名称**：*Dysregulation of ZBTB8OS in colorectal cancer and its association with patient prognosis*
**作者**：Zhang R, et al.
**摘要**：临床样本分析显示，结直肠癌中ZBTB8OS表达显著下调，且低表达与患者生存率负相关。体外实验证实ZBTB8OS过表达可抑制癌细胞迁移和侵袭。
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**建议**：若“ZBTB8OS”为最新命名或罕见变体，请通过**NCBI Gene**或**UniProt**数据库核实标准名称，例如可能为“ZBTB8OS”(假拟)或“ZBTB8A”等类似已知基因。
ZBTB8OS, also known as ZBTB8A or ZNF921. is a human protein belonging to the zinc finger and BTB/POZ domain-containing (ZBTB) family. Characterized by its N-terminal BTB (BROAD-COMPLEX, TRAMTRACK, AND BRIC-À-BRAC) domain and multiple C2H2-type zinc finger motifs, it functions as a transcriptional regulator, potentially involved in DNA binding and protein-protein interactions. While its exact biological role remains under investigation, ZBTB8OS is hypothesized to participate in cellular processes such as differentiation, apoptosis, and chromatin remodeling. Its expression patterns and interactions with other proteins, including tumor suppressors like p53. suggest possible links to cancer pathogenesis. Notably, studies indicate its involvement in regulating genes related to cell cycle control and stress response. Recombinant ZBTB8OS protein, produced via expression systems like E. coli or mammalian cells, enables functional studies, including DNA binding assays, co-immunoprecipitation, and transcriptional activity analysis. Research on ZBTB8OS may offer insights into its role in tumorigenesis, neurological disorders, or immune regulation, highlighting its potential as a therapeutic target. However, comprehensive mechanistic studies are still needed to elucidate its precise molecular pathways and disease associations.
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