| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | UTP15 |
| Uniprot No | Q8TED0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-518 aa |
| 活性数据 | AGYKPVAIQ TYPILGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP PYNYAVTASS RIHIYGRYSQ EPIKTFSRFK DTAYCATFRQ DGRLLVAGSE DGGVQLFDIS GRAPLRQFEG HTKAVHTVDF TADKYHVVSG ADDYTVKLWD IPNSKEILTF KEHSDYVRCG CASKLNPDLF ITGSYDHTVK MFDARTSESV LSVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL LVSLKNHHKT VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALAHE DETIVVGMTN GILSVKHRKS EAKKESLPRR RRPAYRTFIK GKNYMKQRDD ILINRPAKKH LELYDRDLKH FRISKALDRV LDPTCTIKTP EITVSIIKEL NRRGVLANAL AGRDEKEISH VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL PVIGQSPVVD KKFLLLQGLV EKEIDYQREL LETLGMMDML FATMRRKEGT SVLEHTSDGF PENKKIES |
| 分子量 | 58.4 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与重组人UTP15蛋白相关的3条参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**：*Human UTP15 is essential for rRNA processing and ribosome biogenesis*
**作者**：Wang, L. et al.
**摘要概括**：本研究通过体外重组表达人UTP15蛋白，验证其作为U3 snoRNP复合物关键组分在rRNA前体加工中的作用，发现UTP15缺失会导致核糖体亚基组装异常，影响细胞周期进程。
2. **文献名称**：*Recombinant Expression and Functional Analysis of UTP15 in Cancer Cell Proliferation*
**作者**：Zhang, Y. et al.
**摘要概括**：利用大肠杆菌系统表达重组人UTP15蛋白，探究其在肿瘤细胞中的功能。结果显示，UTP15通过调控rRNA成熟促进癌细胞增殖，为潜在肿瘤治疗靶点提供依据。
3. **文献名称**：*Structural Insights into the Role of UTP15 in Small Nucleolar RNPs*
**作者**：Tanaka, K. et al.
**摘要概括**：通过重组人UTP15蛋白的晶体结构解析，揭示其与U3 snoRNA及其他伴侣蛋白的相互作用界面，阐明其在核仁复合物组装中的分子机制。
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注：上述文献为示例，实际文献需根据具体数据库(如PubMed、Google Scholar)检索。若研究较少，可扩展关键词至“UTP15 ribosome biogenesis”或结合相关通路(如“rRNA processing”)查找。
**Background of Human UTP15 Protein**
UTP15 (Utp15 Homolog) is a conserved nucleolar protein integral to ribosome biogenesis, specifically within the small subunit (SSU) processome—a dynamic complex essential for 18S rRNA maturation. As part of the UTP (U Three Protein) complex, UTP15 collaborates with components like UTP14A and UTP4 to mediate pre-rRNA processing, a critical step in ribosome assembly. Structurally, UTP15 contains HEAT-repeat domains, facilitating protein-protein interactions and its role in ribosomal RNA (rRNA) folding and cleavage.
Studies highlight its involvement in cellular proliferation and differentiation, linking dysregulation of UTP15 to pathologies such as cancer. For instance, aberrant expression correlates with tumor progression and poor prognosis in certain cancers, suggesting a role in oncogenic pathways. Recombinant human UTP15 protein, produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), enables functional studies to dissect its molecular mechanisms, interactions, and potential therapeutic targeting. Its applications span in vitro assays, structural analysis, and screening for inhibitors modulating ribosome biogenesis—a promising avenue in cancer therapy. Research continues to explore UTP15’s broader roles in gene expression regulation and cellular stress responses.
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