关键信息
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基因名
uPAR
- 应用
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别名
uPAR；MO3；UPAR；Urokinase plasminogen activator surface receptor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q03405
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表达区间
23-303aa
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氨基酸序列
LRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEK TNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGS SDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYL PGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGN STHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHA HLGDAFSMNHIDVSCCTKSGCNHPDLDVQYR
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
uPAR (urokinase plasminogen activator receptor) is a cell surface receptor that plays a crucial role in various physiological and pathological processes, including tissue remodeling, cell migration, and tumor progression. The uPAR system is involved in the regulation of plasminogen activation, which is essential for proteolysis and extracellular matrix degradation. Studies have indicated that uPAR is overexpressed in various cancers and is associated with aggressive tumor behavior, making it a potential biomarker for cancer diagnosis and prognosis. Moreover, uPAR is implicated in inflammatory processes, wound healing, and fibrosis. Research has focused on the structural and functional characterization of uPAR and the development of uPAR-targeted therapies, including antibody-drug conjugates and small molecules that can inhibit its function. The generation of recombinant uPAR proteins has facilitated the study of its interactions and signaling pathways, enabling researchers to explore its role in cellular processes at a molecular level. Understanding the biochemistry and biology of uPAR is critical for developing novel therapeutic strategies aimed at targeting this receptor in cancer and other diseases, ultimately improving patient outcomes through precision medicine approaches.
