| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | UBXN6 |
| Uniprot No | Q9BZV1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-441 aa |
| 活性数据 | MKKFFQEFKA DIKFKSAGPG QKLKESVGEK AHKEKPNQPA PRPPRQGPTN EAQMAAAAAL ARLEQKQSRA WGPTSQDTIR NQVRKELQAE ATVSGSPEAP GTNVVSEPRE EGSAHLAVPG VYFTCPLTGA TLRKDQRDAC IKEAILLHFS TDPVAASIMK IYTFNKDQDR VKLGVDTIAK YLDNIHLHPE EEKYRKIKLQ NKVFQERINC LEGTHEFFEA IGFQKVLLPA QDQEDPEEFY VLSETTLAQP QSLERHKEQL LAAEPVRAKL DRQRRVFQPS PLASQFELPG DFFNLTAEEI KREQRLRSEA VERLSVLRTK AMREKEEQRG LRKYNYTLLR VRLPDGCLLQ GTFYARERLG AVYGFVREAL QSDWLPFELL ASGGQKLSED ENLALNECGL VPSALLTFSW DMAVLEDIKA AGAEPDSILK PELLSAIEKL L |
| 分子量 | 49.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人UBXN6蛋白的参考文献示例(注：以下内容为模拟虚构，仅供格式参考)：
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1. **文献名称**: "UBXN6 inhibits NF-κB signaling by binding to and disrupting the ubiquitination of TRAF6"
**作者**: Kuang, Z., et al.
**摘要**: 本研究阐明了重组人UBXN6蛋白通过直接结合TRAF6.干扰其K63泛素化修饰，从而抑制NF-κB通路的激活，揭示了UBXN6在炎症反应中的负调控作用。
2. **文献名称**: "Structural analysis of UBXN6 reveals a conserved UBX domain critical for p97/VCP interaction"
**作者**: Sasaki, T., et al.
**摘要**: 利用重组UBXN6蛋白的晶体结构解析，发现其UBX结构域中的关键氨基酸残基对p97/VCP蛋白的ATP酶活性具有调控功能，为UBXN6参与蛋白酶体降解通路提供了结构基础。
3. **文献名称**: "UBXN6 promotes apoptosis by stabilizing the interaction between p97 and pro-apoptotic substrates"
**作者**: Dulitz, S.J., et al.
**摘要**: 研究发现，重组UBXN6蛋白通过增强p97与促凋亡底物的结合，促进Caspase-8的激活，进而诱导细胞凋亡，表明其在细胞命运决定中的双向调控作用。
4. **文献名称**: "UBXN6 regulates NLRP3 inflammasome activation through modulating ASC ubiquitination"
**作者**: Hu, R., et al.
**摘要**: 实验表明，重组UBXN6蛋白通过调节炎性小体接头蛋白ASC的泛素化水平，抑制NLRP3炎症小体的过度活化，为治疗炎症性疾病提供了潜在靶点。
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**备注**：以上文献为示例性内容，实际研究中请通过PubMed、Web of Science等平台检索最新文献。如需具体文章，可提供数据库访问权限进一步协助查询。
UBXN6 (UBX Domain Protein 6) is a member of the UBXD protein family, characterized by a conserved UBX domain that facilitates interactions with p97/VCP, a key ATPase involved in ubiquitin-dependent processes. This protein plays a regulatory role in the ubiquitin-proteasome system, which governs protein degradation and quality control. UBXN6 is implicated in endoplasmic reticulum-associated degradation (ERAD), aiding in the clearance of misfolded proteins by linking ubiquitinated substrates to p97/VCP for extraction and proteasomal targeting. Studies suggest its involvement in cell cycle regulation, stress responses, and apoptosis, with potential ties to cancers and neurodegenerative diseases. Recombinant human UBXN6 protein, produced via expression systems like *E. coli* or mammalian cells, retains functional domains for biochemical studies, enabling research on its structure, interactome, and mechanistic roles. Its recombinant form is pivotal in dissecting pathways related to protein homeostasis and developing therapeutic strategies targeting ubiquitination dysregulation. Ongoing research aims to clarify its tissue-specific functions and therapeutic relevance in diseases marked by proteostasis imbalance.
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