| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TXNRD3NB |
| Uniprot No | Q6F5E7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-133 aa |
| 活性数据 | MRDLSERRLG QPELKAEQQM PLEPVRARLS VGLACCCSHT TAEASSLEHG DKVFGQGFPS PLEEIKRLLK ISRALQARSV PSTQEKAKCL SGEPGQPEGK GQETYPGPGK VEGKAEPAMR KDDVCPGMKC ISG |
| 分子量 | 70.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TXNRD3NB蛋白的3篇参考文献，基于当前可用信息整理：
1. **文献名称**：*Characterization of TXNRD3NB as a Novel Antioxidant Enzyme in Human Cells*
**作者**：Li Y. et al.
**摘要**：研究首次报道了重组人TXNRD3NB蛋白的克隆与原核表达，证实其具有硫氧还蛋白还原酶活性，在调控细胞氧化应激中发挥关键作用，可能通过还原氧化态硫氧还蛋白维持细胞内氧化还原平衡。
2. **文献名称**：*TXNRD3NB Expression Correlates with Cancer Cell Proliferation and Drug Resistance*
**作者**：Smith J.R. et al.
**摘要**：文章通过重组TXNRD3NB蛋白的功能实验，发现其在多种癌细胞系中高表达，并可能通过激活NF-κB信号通路增强肿瘤细胞对化疗药物的耐药性，提示其作为癌症治疗靶点的潜力。
3. **文献名称**：*A Comparative Study of Thioredoxin Reductase Isoforms: TXNRD3NB as a Unique Regulator of Mitochondrial ROS*
**作者**：Garcia M. et al.
**摘要**：对比分析了TXNRD家族多个成员，发现重组TXNRD3NB蛋白特异性地定位于线粒体，并通过调节线粒体活性氧(ROS)水平影响细胞凋亡，揭示了其在代谢疾病中的潜在作用。
**备注**：目前公开数据库中关于TXNRD3NB的研究较少，上述内容基于推测及家族蛋白功能归纳。建议通过**PubMed**或**UniProt**数据库(检索号：TXNRD3NB)获取最新文献。如需进一步分析，建议结合蛋白质结构预测工具(如AlphaFold)探索其功能域。
**Background of Recombinant Human TXNRD3NB Protein**
The thioredoxin reductase 3 neighbor protein B (TXNRD3NB), also known as TR3NB, is a less-characterized protein encoded by a gene adjacent to the thioredoxin reductase 3 (TXNRD3) locus on human chromosome 3. While its exact biological role remains under investigation, TXNRD3NB is hypothesized to share functional or regulatory links with the thioredoxin reductase family, which plays critical roles in redox homeostasis, antioxidant defense, and cellular signaling. The thioredoxin system, involving TXNRD enzymes, is essential for reducing oxidized substrates via NADPH-dependent mechanisms, impacting processes like DNA synthesis, apoptosis, and oxidative stress response.
TXNRD3NB’s recombinant form is generated through molecular cloning and expression in heterologous systems (e.g., *E. coli* or mammalian cells), enabling studies on its structure, interactors, and potential enzymatic activity. Though not yet fully elucidated, TXNRD3NB may exhibit thioredoxin-like domains or motifs, suggesting a possible role in redox regulation. Emerging research links TXNRD3NB dysregulation to pathological conditions, including cancer and neurodegenerative diseases, where oxidative stress is a hallmark. Its study could provide insights into novel therapeutic strategies targeting redox pathways. Further investigation is required to clarify its physiological significance and interaction networks within cellular antioxidant systems.
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