| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TSGA10IP |
| Uniprot No | Q3SY00 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-556 aa |
| 活性数据 | MGQDTDMLNT YQQLVRTPSV RPGQDVRLQA PGTRTGLLKL LSTVSQDKQG CLGSGDGVPN QDLQQRSQSS RQTAKKDRKP RGQSKKGQGS EESEDHFPLL PRKPSFPFQW AWESIATDVR AVLQPSSPTP GHQALPMPSS FSQRQSRRKS TANLPEAHGC CWKTEAQNLK ARQQLGAWGG VSIPTGKGEL GSEPPSGLQL PGRRPGSGSA SDKQVQLQSL GAEEAERGLS SGVLPQRPRR GSISEEEQFS EATEEAEEGE HRTPCRRRAG CQRKGQISGE EASDEGEVQG QSQGSSPSFN NLRRRQWRKT RAKELQGPWD LEKLHRQLQR DLDCGPQKLP WKTLRAAFQA SKRNGKAYAS GYDETFVSAN LPNRTFHKRQ EATRSLLQAW ERQRQEERQQ AELRRARTQH VQRQVAHCLA AYAPRGSRGP GAAQRKLEEL RRQERQRFAE YQAELQGIQH RVQARPFLFQ QAMQANARLT VTRRFSQVLS ALGLDEEQLL SEAGKVDREG TPRKPRSHRS VGVRMEHSPQ RPPRTEPTGS QPDRHYNPSL DPECSP |
| 分子量 | 62.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是与重组人TSGA10IP蛋白相关的文献示例(内容为模拟生成，仅供参考)：
1. **文献名称**: "TSGA10IP is essential for sperm head shaping and male fertility in mice"
**作者**: Zhang Y, et al.
**摘要**: 该研究发现TSGA10IP蛋白在小鼠精子头部形成中起关键作用，其缺失导致精子形态异常及雄性不育，提示其在生殖细胞发育中的功能。
2. **文献名称**: "Structural insights into TSGA10IP interaction with HSP70 in ciliogenesis regulation"
**作者**: Kumar S, et al.
**摘要**: 通过X射线晶体学解析TSGA10IP与HSP70复合物的结构，揭示了其在纤毛发生中调控分子伴侣活性的分子机制，为纤毛相关疾病提供新线索。
3. **文献名称**: "Overexpression of recombinant TSGA10IP suppresses tumor growth in glioma models"
**作者**: Wang L, et al.
**摘要**: 研究构建了重组TSGA10IP蛋白，并证明其能通过抑制PI3K/AKT通路降低胶质瘤细胞增殖和侵袭，提示其潜在抗肿瘤应用价值。
4. **文献名称**: "Proteomic analysis identifies TSGA10IP as a novel hypoxia-responsive protein in breast cancer"
**作者**: Chen H, et al.
**摘要**: 通过蛋白质组学发现TSGA10IP在乳腺癌缺氧微环境中显著上调，可能通过调控VEGF信号促进血管生成，成为潜在治疗靶点。
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注：上述文献信息为示例，实际引用需以真实发表的论文为准。若需准确文献，建议在PubMed或Web of Science中使用关键词“TSGA10IP”或“TSGA10 interacting protein”检索，并结合研究领域(如生殖生物学、癌症、纤毛疾病)筛选。
TSGA10IP (Testis-Specific Gene Antigen 10 Interacting Protein), also known as SPATA24 or CCDC81. is a human protein encoded by the *TSGA10IP* gene. It is primarily expressed in the testis and plays a critical role in spermatogenesis, particularly in the structural organization of sperm components. TSGA10IP is recognized for its interaction with TSGA10. a hypoxia-inducible protein involved in sperm head elongation and tail formation. Both proteins are localized to the sperm tail and midpiece, suggesting their cooperative function in sperm motility and structural integrity.
Structurally, TSGA10IP contains coiled-coil domains, which facilitate protein-protein interactions and cytoskeletal organization. Studies indicate its involvement in ciliogenesis, cell cycle regulation, and centriole duplication, linking it to broader cellular processes beyond reproduction. Dysregulation of TSGA10IP has been associated with male infertility due to impaired sperm development. Emerging research also explores its potential role in cancer, as altered expression has been observed in certain tumors, possibly influencing cell proliferation or metastasis.
Recombinant TSGA10IP protein is typically produced in *E. coli* or mammalian expression systems for functional studies. It serves as a tool to investigate molecular mechanisms in gametogenesis, cilia-related disorders, and cancer biology. Current research aims to clarify its precise molecular interactions, signaling pathways, and therapeutic applications in reproductive medicine and oncology.
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