| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FOXP1 |
| Uniprot No | Q9H334-5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-114aa |
| 氨基酸序列 | MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAAD LAHAQQQQQQWHLINHQPSRSPSSWLKRLISSPWELEVLQVPLWGAVAET KMSGPVCQPNPSPF |
| 预测分子量 | 38 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于FOXP1重组蛋白的3篇参考文献示例(注：文献信息为模拟虚构，仅供格式参考)：
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1. **标题**: *FOXP1重组蛋白通过调控Wnt信号通路抑制肺癌细胞迁移*
**作者**: Zhang, L. et al.
**摘要**: 本研究利用重组FOXP1蛋白处理肺癌细胞系，发现其通过抑制Wnt/β-catenin通路活性，降低肿瘤细胞的侵袭能力，提示FOXP1可能作为肺癌治疗的潜在靶点。
2. **标题**: *FOXP1 DNA结合域的结构解析及其转录调控机制*
**作者**: Thompson, R.K. & Shapiro, M.
**摘要**: 通过X射线晶体学解析重组FOXP1蛋白的DNA结合域结构，揭示其与特定DNA序列的相互作用模式，为FOXP1突变导致语言障碍的分子机制提供结构依据。
3. **标题**: *重组FOXP1蛋白在B细胞分化中的动态功能研究*
**作者**: Wang, Y. et al.
**摘要**: 利用重组FOXP1蛋白进行体外B细胞分化实验，证明FOXP1通过调控PAX5等关键基因表达，影响B细胞发育及抗体多样性生成。
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**备注**：若需真实文献，建议通过PubMed或Google Scholar检索关键词“FOXP1 recombinant protein”或结合研究领域(如癌症、神经发育)筛选近年论文。
FOXP1 (Forkhead Box P1) is a member of the FOX family of transcription factors, characterized by a conserved forkhead DNA-binding domain. It plays critical roles in embryonic development, immune regulation, and cellular differentiation. Initially identified through its homology to FOXP3. a key regulator of T-cell function, FOXP1 is broadly expressed in tissues such as the brain, heart, and hematopoietic system. It regulates gene expression by binding to promoter regions, often in cooperation with other transcription factors, and participates in pathways governing cell proliferation, apoptosis, and organogenesis.
Recombinant FOXP1 protein is engineered to study its molecular functions and interactions in vitro. Produced using expression systems like *E. coli* or mammalian cells, the protein retains functional domains, including the forkhead domain, zinc finger motifs, and a leucine zipper for dimerization. Researchers utilize it to investigate DNA-binding specificity, protein-protein interactions, and its role in developmental disorders. Mutations in *FOXP1* are linked to neurodevelopmental conditions (e.g., autism, intellectual disability) and congenital heart defects, making recombinant protein crucial for mechanistic studies.
In cancer biology, FOXP1 exhibits dual roles, acting as a tumor suppressor or oncogene depending on context. Dysregulation is observed in lymphomas, breast cancer, and gliomas. Recombinant FOXP1 aids in drug screening and biomarker discovery. Additionally, it serves as a tool for gene therapy research, particularly in restoring functional deficits caused by mutations. Despite progress, challenges remain in understanding tissue-specific isoforms and post-translational modifications. Ongoing work aims to clarify its therapeutic potential and molecular dynamics in health and disease.
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