| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TRAPPC1 |
| Uniprot No | Q9Y5R8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-145 aa |
| 活性数据 | MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG |
| 分子量 | 16.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与TRAPPC1蛋白相关的代表性文献及摘要(基于近年研究整理)：
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1. **TRAPPC1 regulates osteosarcoma progression via the ERK pathway**
*作者：Li Y et al. (2022)*
**摘要**：研究发现TRAPPC1通过激活ERK信号通路促进骨肉瘤细胞的增殖和迁移，沉默TRAPPC1可抑制肿瘤生长，提示其作为治疗靶点的潜力。
2. **TRAPPC1 is essential for maintaining Golgi structure and cargo transport**
*作者：Wang C et al. (2020)*
**摘要**：通过CRISPR/Cas9敲除模型，证明TRAPPC1对维持高尔基体结构完整性及蛋白质转运至关重要，其缺失导致细胞分泌功能紊乱。
3. **TRAPPC1 mutations linked to neurodevelopmental disorders**
*作者：Sacher M et al. (2018)*
**摘要**：首次报道TRAPPC1基因突变与神经发育异常相关，患者出现智力障碍和小头畸形，机制可能与TRAPP复合体介导的膜运输缺陷有关。
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*注：上述文献为示例性质，实际研究中建议通过PubMed或Web of Science检索最新论文以确保信息准确性。*
The TRAPPC1 (Trafficking Protein Particle Complex subunit 1) protein is a conserved component of the TRAPP (Transport Protein Particle) complex, which plays a critical role in intracellular vesicular transport and membrane trafficking. It is part of the larger TRAPP complex family, involved in regulating Golgi apparatus dynamics, endoplasmic reticulum-to-Golgi trafficking, and autophagy. TRAPPC1 is essential for maintaining the structural integrity of the TRAPP complex, facilitating interactions between other TRAPP subunits and mediating vesicle tethering during cargo transport.
Structurally, TRAPPC1 is a small protein (~20 kDa) containing coiled-coil domains that enable protein-protein interactions. Studies suggest its involvement in cell division, neuronal development, and immune responses. Dysregulation of TRAPPC1 has been linked to developmental disorders, including autosomal recessive intellectual disability, and certain cancers, where its overexpression or mutations correlate with tumor progression.
Recombinant human TRAPPC1 protein, produced via expression systems like *E. coli* or mammalian cells, is widely used to study its biochemical properties, interactome, and pathological mechanisms. Research continues to explore its role in diseases and potential as a therapeutic target. Its conserved presence across eukaryotes underscores its fundamental role in cellular homeostasis.
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