| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TRAF3IP2 |
| Uniprot No | O43734 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-574 aa |
| 活性数据 | MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN MAPNSLSAPT MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS EDSFCRRHPG LGKAFPSGCS AVSEPASESV VGALPAEHQF SFMEKRNQWL VSQLSAASPD TGHDSDKSDQ SLPNASADSL GGSQEMVQRP QPHRNRAGLD LPTIDTGYDS QPQDVLGIRQ LERPLPLTSV CYPQDLPRPL RSREFPQFEP QRYPACAQML PPNLSPHAPW NYHYHCPGSP DHQVPYGHDY PRAAYQQVIQ PALPGQPLPG ASVRGLHPVQ KVILNYPSPW DHEERPAQRD CSFPGLPRHQ DQPHHQPPNR AGAPGESLEC PAELRPQVPQ PPSPAAVPRP PSNPPARGTL KTSNLPEELR KVFITYSMDT AMEVVKFVNF LLVNGFQTAI DIFEDRIRGI DIIKWMERYL RDKTVMIIVA ISPKYKQDVE GAESQLDEDE HGLHTKYIHR MMQIEFIKQG SMNFRFIPVL FPNAKKEHVP TWLQNTHVYS WPKNKKNILL RLLREEEYVA PPRGPLPTLQ VVPL |
| 分子量 | 64.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人TRAF3IP2蛋白的3篇代表性文献及其摘要概括：
1. **文献名称**: *"TRAF3IP2 mediates IL-17-induced signaling through NF-κB and MAPK pathways in autoimmune inflammation"*
**作者**: Qian Y. et al.
**摘要**: 研究发现TRAF3IP2作为IL-17信号通路的关键适配蛋白，通过激活NF-κB和MAPK通路促进炎症因子(如IL-6、TNF-α)的产生，揭示了其在自身免疫性疾病(如银屑病)中的作用机制。
2. **文献名称**: *"Genetic variants in TRAF3IP2 are associated with psoriasis vulgaris in a Chinese population"*
**作者**: Wang C. et al.
**摘要**: 通过对中国人群的全基因组关联分析，发现TRAF3IP2基因的单核苷酸多态性(SNPs)与银屑病风险显著相关，提示其可能通过调控IL-17/IL-23信号通路参与皮肤炎症的病理过程。
3. **文献名称**: *"TRAF3IP2 regulates mitochondrial dysfunction and oxidative stress in atherosclerosis"*
**作者**: Garg A. et al.
**摘要**: 该文献揭示TRAF3IP2通过促进血管内皮细胞线粒体功能障碍和活性氧(ROS)积累加剧动脉粥样硬化，表明靶向TRAF3IP2可能成为心血管疾病的潜在治疗策略。
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以上研究覆盖了TRAF3IP2在炎症信号传导、疾病遗传关联及代谢调控中的多维度作用，可为基础研究和疾病治疗提供参考。
TRAF3-interacting protein 2 (TRAF3IP2), also known as ACT1 or CIKS, is a cytoplasmic adaptor protein critical in regulating inflammatory and immune responses. It belongs to the TRAF-interacting protein family and serves as a signaling mediator, primarily linking interleukin-17 (IL-17) receptor activation to downstream pathways like NF-κB and MAPK. Structurally, TRAF3IP2 contains an N-terminal homologous domain and a C-terminal TRAF-binding motif, enabling interactions with TRAF proteins (e.g., TRAF3. TRAF6) and other signaling components.
Functionally, TRAF3IP2 plays a dual role: it promotes IL-17-induced pro-inflammatory cytokine production (e.g., IL-6. TNF-α) by facilitating TRAF6-dependent NF-κB activation, while also negatively regulating TLR and CD40 signaling through TRAF3 degradation. Its involvement in IL-17 signaling underscores its importance in host defense, but dysregulation contributes to chronic inflammation and autoimmunity. Genome-wide studies link TRAF3IP2 polymorphisms (e.g., rs33980500) to increased susceptibility to psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.
Emerging evidence suggests TRAF3IP2’s role in cancer, where it may drive pro-tumorigenic inflammation. Preclinical studies targeting TRAF3IP2 with small-molecule inhibitors or monoclonal antibodies show promise in mitigating autoimmune pathologies, highlighting its therapeutic potential. Overall, TRAF3IP2 is a key molecular switch balancing immune homeostasis and inflammation, making it a focal point in understanding and treating immune-mediated diseases.
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