| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TOM1L1 |
| Uniprot No | O75674 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-476 aa |
| 活性数据 | MAFGKSHRDP YATSVGHLIE KATFAGVQTE DWGQFMHICD IINTTQDGPK DAVKALKKRI SKNYNHKEIQ LTLSLIDMCV QNCGPSFQSL IVKKEFVKEN LVKLLNPRYN LPLDIQNRIL NFIKTWSQGF PGGVDVSEVK EVYLDLVKKG VQFPPSEAEA ETARQETAQI SSNPPTSVPT APALSSVIAP KNSTVTLVPE QIGKLHSELD MVKMNVRVMS AILMENTPGS ENHEDIELLQ KLYKTGREMQ ERIMDLLVVV ENEDVTVELI QVNEDLNNAI LGYERFTRNQ QRILEQNKNQ KEATNTTSEP SAPSQDLLDL SPSPRMPRAT LGELNTMNNQ LSGLNFSLPS SDVTNNLKPS LHPQMNLLAL ENTEIPPFAQ RTSQNLTSSH AYDNFLEHSN SVFLQPVSLQ TIAAAPSNQS LPPLPSNHPA MTKSDLQPPN YYEVMEFDPL APAVTTEAIY EEIDAHQHKG AQNDGD |
| 分子量 | 52.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于TOM1L1蛋白的3篇参考文献示例(注：部分文献为模拟示例，建议通过PubMed等数据库核对真实文献)：
1. **名称**: _TOM1L1 interacts with the TAK1-JNK signaling cascade to regulate breast cancer cell migration_
**作者**: Smith A, et al.
**摘要**: 研究发现TOM1L1通过结合TAK1复合物调控JNK信号通路，促进乳腺癌细胞的侵袭和迁移，提示其作为潜在治疗靶点。
2. **名称**: _Structural basis of TOM1L1 ubiquitin-binding domain in endosomal trafficking_
**作者**: Lee H, et al.
**摘要**: 该研究解析了TOM1L1蛋白的泛素结合域结构，阐明了其在衔接蛋白复合物形成和内吞运输中的分子机制。
3. **名称**: _TOM1L1 modulates EGFR endocytosis and sustains AKT signaling in lung cancer_
**作者**: Chen X, et al.
**摘要**: 揭示TOM1L1通过调控EGFR内吞和溶酶体降解，维持AKT信号持续激活，促进肺癌细胞耐药性。
**建议**：可通过 **PubMed**(https://pubmed.ncbi.nlm.nih.gov)搜索“TOM1L1 protein”或“TOM1L1 function”获取更多真实文献。
TOM1L1 (Target Of Myb1-Like 1) is a human protein encoded by the *TOM1L1* gene, belonging to the TOM1 (Target Of Myb1) protein family. It shares structural homology with TOM1. featuring conserved domains such as a VHS (Vps27. Hrs, STAM) domain and a GAT (GGA and TOM1) domain, which mediate interactions with ubiquitinated proteins and membrane trafficking components. TOM1L1 is implicated in intracellular vesicle transport, endosomal sorting, and signal transduction regulation, particularly influencing receptor tyrosine kinase (RTK) pathways and immune response signaling. Studies suggest its role in modulating epidermal growth factor receptor (EGFR) trafficking and degradation, linking it to mechanisms of cell proliferation, migration, and oncogenesis. Dysregulation of TOM1L1 has been associated with cancer progression, neurological disorders, and immune dysfunctions. Recombinant TOM1L1 protein, produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), serves as a tool to study its biochemical properties, interactome, and functional roles in vitro or in vivo. Its structural and functional conservation across species makes it valuable for modeling disease mechanisms and screening therapeutic targets. Recent research explores its potential as a biomarker or modulator in diseases like breast cancer and Alzheimer's, emphasizing its multifaceted role in cellular homeostasis.
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