关键信息
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基因名
RCAN2
- 应用
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别名
Calcipressin 2; Calcipressin-2; CSP2; Down syndrome candidate region 1-like 1; Down syndrome critical region gene 1 like 1 protein; DSCR1L1; MCIP2; Myocyte enriched calcineurin interacting protein 2; Myocyte-enriched calcineurin-interacting protein 2; RCAN2; RCAN2_HUMAN; RCN2; Regulator of calcineurin 2; Thyroid hormone responsive gene ZAKI4; Thyroid hormone responsive protein ZAKI4; thyroid hormone-responsive (skin fibroblasts); Thyroid hormone-responsive protein ZAKI-4; ZAKI4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14206
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表达区间
1-197 aa
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氨基酸序列
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN
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分子量
21.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
RCAN2 (Regulator of Calcineurin 2) is a critical protein that plays significant roles in various cellular processes, including calcium signaling, neuronal differentiation, and stress responses. It is a member of the RCAN family, which is known for modulating the activity of calcineurin, a calcium-dependent phosphatase that influences numerous signaling pathways. The dysregulation of RCAN2 has been associated with several pathological conditions, including neurodegenerative diseases, cardiovascular disorders, and certain cancers. Research has shown that RCAN2 can affect the transcriptional activity of NFAT (Nuclear Factor of Activated T-cells), a crucial factor in immune responses and cardiac development. Consequently, understanding the molecular mechanisms underlying RCAN2's functionality could reveal new therapeutic targets for these diseases. Recombinant RCAN2 protein studies facilitate the elucidation of its structure-function relationship, interactions with calcineurin, and its downstream signaling pathways. This research not only provides insights into the fundamental biology of RCAN2 but also paves the way for potential clinical applications, as manipulating RCAN2 levels or activity may offer novel strategies for treatment in conditions where calcium signaling is disrupted.
