关键信息
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基因名
PDGF-AA
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简介
PDGF-A protein is a key growth factor that regulates embryonic development, cell proliferation, migration, survival, and chemotaxis, and exerts potent mitogenic effects on mesenchymal cells. It is essential for alveolar septal formation, gastrointestinal tract development, interstitial cell maturation, spermatogenesis, and oligodendrocyte development, and contributes to spinal cord and cerebellar myelination. PDGF-AA Protein, Human is the recombinant human-derived PDGF-AA protein, expressed by E. coli , with tag free.
- 应用
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别名
PDGFAA; PDGF-AA
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by reducing SDS-PAGE.
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蛋白编号
P04085-1
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表达区间
S87-T211
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Platelet-derived growth factor AA (PDGF-AA) is a significant protein involved in various biological processes, particularly in cell growth, development, and tissue repair. As a member of the PDGF family, PDGF-AA is primarily secreted by platelets and plays a crucial role in the regulation of cell proliferation and differentiation, particularly in connective tissues. Its mechanisms of action are mediated through specific receptors, leading to various downstream signaling pathways that influence angiogenesis, wound healing, and fibrogenesis. Recent studies have highlighted PDGF-AA's implications in pathological conditions such as fibrosis, cancer, and vascular diseases, making it a target of interest for therapeutic interventions. Recombinant PDGF-AA protein has garnered attention in research settings for its potential applications in regenerative medicine, particularly in enhancing tissue repair and modulating fibrotic processes. The ability to produce PDGF-AA in a recombinant form allows for detailed studies of its biological functions and interactions within the extracellular matrix, paving the way for potential clinical applications. Ongoing research aims to elucidate its role in cellular mechanisms and explore its therapeutic efficacy in various disease models, emphasizing the importance of PDGF-AA in both fundamental biology and translational medicine.
