Cat: PA2000-2099

Recombinant Human MRPL19 Protein,His

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关键信息

  • 基因名

    MRPL19

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    MRPL19;KIAA1917;E3 ubiquitin ligase RNF157

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P49406

  • 表达区间

    1-292aa

  • 氨基酸序列

    MAACIAAGHWAAMGLGRSFQAARTLLPPPASIACRVHAGPVRQQSTGPSEPGAFQPPPKPVIVDKHRPVEPERRFLSPEFIPRRGRTDPLKFQIERKDMLERRKVLHIPEFYVGSILRVTTADPYASGKISQFLGICIQRSGRGLGATFILRNVIEGQGVEICFELYNPRVQEIQVVKLEKRLDDSLLYLRDALPEYSTFDVNMKPVVQEPNQKVPVNELKVKMKPKPWSKRWERPNFNIKGIRFDLCLTEQQMKEAQKWNQPWLEFDMMREYDTSKIEAAIWKEIEASKRS

  • 分子量

    60.5 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

MRPL19, a mitochondrial ribosomal protein, is essential for the proper assembly and function of the mitochondrial ribosome, contributing to the synthesis of proteins crucial for mitochondrial function and energy production. The study of MRPL19 has gained significance due to its potential implications in various diseases, particularly in the context of mitochondrial dysfunction which is linked to degenerative diseases, metabolic disorders, and aging. Mutations or dysregulation of MRPL19 can lead to impaired mitochondrial protein synthesis, resulting in decreased cellular energy metabolism and increased oxidative stress. This has spurred interest in understanding the molecular mechanisms by which MRPL19 operates within mitochondrial biogenesis and its role in cellular responses to stress. Researchers are exploring MRPL19 as a potential biomarker for mitochondrial diseases and its significance in therapeutic interventions aimed at restoring mitochondrial function. Understanding the structure-function relationship of MRPL19 and its interaction with other mitochondrial components is crucial for developing targeted treatments that can mitigate the effects of mitochondrial dysfunction. Advances in recombinant protein technology have facilitated the production of MRPL19, allowing for in-depth biochemical studies that elucidate its role in mitochondrial translation and overall cellular health. Given the critical nature of mitochondrial function in energy metabolism and cellular signaling, the ongoing research on MRPL19 not only broadens the understanding of mitochondrial biology but also opens avenues for innovative approaches in treating mitochondrial-related diseases.

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