关键信息
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基因名
Angiopoietin-2
- 应用
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别名
ANG2; AGPT2
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 97% as determined by SDS-PAGE.
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蛋白编号
O35462
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表达区间
Gln33~Val243
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蛋白长度
Partial
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分子量
25kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
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背景信息
Angiopoietin-2 (Ang-2) is a pivotal regulator of angiogenesis, playing a critical role in vascular development, homeostasis, and inflammation. It functions as a natural antagonist to Angiopoietin-1 (Ang-1), which promotes vessel stability and maturation by activating the Tie2 receptor. Under pathological conditions, such as tumor growth, chronic inflammation, and cardiovascular diseases, the expression of Ang-2 is upregulated, leading to increased vascular permeability and aberrant angiogenesis. This has positioned Ang-2 as a potential therapeutic target; therefore, understanding its functional mechanisms is of paramount importance. The development of recombinant Ang-2 proteins has facilitated the exploration of its role in these processes, enabling researchers to elucidate its interactions with various cellular pathways and its impact on endothelial cell behavior. Furthermore, recombinant Ang-2 has been investigated as a biomarker for disease progression and a potential target for therapeutic interventions, particularly in oncology and vascular-related disorders. By studying the properties and effects of Ang-2, researchers aim to develop new strategies for modulating angiogenesis, ultimately leading to innovative treatments that can manage diseases characterized by dysregulated blood vessel formation. The advances in recombinant protein technologies have also allowed for detailed structural and functional analyses of Ang-2, enhancing our understanding of its mechanism of action and paving the way for the development of Ang-2 inhibitors or modulators that could benefit clinical outcomes in various disease settings. Overall, the investigation of recombinant Angiopoietin-2 is a promising field that combines molecular biology, therapeutic development, and clinical application, with potential implications for treating a range of vascular and oncological conditions.
