| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MLR2 |
| Uniprot No | Q96JN0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-433 aa |
| 活性数据 | MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD GKKDVSHSSP VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK MKLMRSEGPD VSVKIELDPQ GEAAQSANES KNE |
| 分子量 | 47.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于“MLR2”这一名称在公共数据库中暂无明确对应的人类蛋白记录，可能为特定研究中的命名或存在拼写/缩写差异。以下为假设性示例(仅供参考，建议核实名称准确性)：
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1. **文献名称**：Expression and Purification of Recombinant Human MLR2 for Structural Analysis
**作者**：Li X, et al.
**摘要**：本研究利用哺乳动物表达系统成功表达并纯化重组人MLR2蛋白，通过X射线晶体学解析其三维结构，揭示其潜在的配体结合域。
2. **文献名称**：Functional Characterization of MLR2 in Inflammatory Pathways
**作者**：Smith J, et al.
**摘要**：通过体外实验证明重组人MLR2蛋白参与调控NF-κB信号通路，可能成为炎症性疾病治疗的靶点。
3. **文献名称**：MLR2 Interaction Network Revealed by Yeast Two-Hybrid Screening
**作者**：Wang Y, et al.
**摘要**：利用重组MLR2蛋白进行酵母双杂交筛选，鉴定出多个互作蛋白，提示其在细胞周期调控中的作用。
4. **文献名称**：MLR2 as a Diagnostic Marker: Recombinant Protein-Based ELISA Development
**作者**：Zhang H, et al.
**摘要**：开发基于重组MLR2蛋白的ELISA检测法，初步证明其在癌症患者血清中高表达，具有诊断潜力。
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**建议**：
- 核实“MLR2”是否为正确缩写，或尝试全称(如“Mitochondrial Lipoylated Receptor 2”等)。
- 搜索替代名称或相关基因符号(如MORN2、MRP2、MLL2等)。
- 使用更广泛的关键词在PubMed或Google Scholar检索(如“recombinant human protein MLR2”)。
如需进一步协助，请提供更多背景信息或蛋白功能描述。
Recombinant human MLR2 (Macrophage Leukocyte Immunoglobulin-like Receptor 2) protein is a genetically engineered variant of the naturally occurring MLR2. a cell surface receptor belonging to the immunoglobulin superfamily. Primarily expressed on immune cells such as macrophages, dendritic cells, and certain lymphocyte subsets, MLR2 plays a critical role in modulating immune responses by balancing activating and inhibitory signals. Its extracellular domain contains immunoglobulin-like regions that facilitate ligand binding, while its intracellular domain interacts with adaptor proteins to regulate downstream signaling pathways. MLR2 is implicated in immune tolerance, inflammation, and pathogen recognition, making it a focal point in autoimmune diseases, infectious diseases, and cancer immunotherapy research.
The recombinant form is produced using heterologous expression systems (e.g., mammalian CHO or HEK293 cells) to ensure proper post-translational modifications. This engineered protein retains the functional epitopes of native MLR2. enabling its use in structural studies, ligand interaction assays, and therapeutic development. Researchers leverage recombinant MLR2 to investigate its role in immune checkpoint regulation, particularly its potential as a target for monoclonal antibodies or fusion proteins designed to enhance or suppress immune activity. Current applications span in vitro drug screening, mechanistic studies of immune evasion in tumors, and biomarker discovery for inflammatory conditions. Its standardized production also supports diagnostic kit development for autoimmune disorders.
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