| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MAMDC2 |
| Uniprot No | Q7Z304 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 19-686aa |
| 活性数据 | LD LPAGSCAFEE STCGFDSVLA SLPWILNEEG HYIYVDTSFG KQGEKAVLLS PDLQAEEWSC LRLVYQITTS SESLSDPSQL NLYMRFEDES FDRLLWSAKE PSDSWLIASL DLQNSSKKFK ILIEGVLGQG NTASIALFEI KMTTGYCIEC DFEENHLCGF VNRWNPNVNW FVGGGSIRNV HSILPQDHTF KSELGHYMYV DSVYVKHFQE VAQLISPLTT APMAGCLSFY YQIQQGNDNV FSLYTRDVAG LYEEIWKADR PGNAAWNLAE VEFSAPYPME VIFEVAFNGP KGGYVALDDI SFSPVHCQNQ TELLFSAVEA SCNFEQDLCN FYQDKEGPGW TRVKVKPNMY RAGDHTTGLG YYLLANTKFT SQPGYIGRLY GPSLPGNLQY CLRFHYAIYG FLKMSDTLAV YIFEENHVVQ EKIWSVLESP RGVWMQAEIT FKKPMPTKVV FMSLCKSFWD CGLVALDDIT IQLGSCSSSE KLPPPPGECT FEQDECTFTQ EKRNRSSWHR RRGETPTSYT GPKGDHTTGV GYYMYIEASH MVYGQKARLL SRPLRGVSGK HCLTFFYHMY GGGTGLLSVY LKKEEDSEES LLWRRRGEQS ISWLRALIEY SCERQHQIIF EAIRGVSIRS DIAIDDVKFQ AGPCGEMEDT TQQSSGYSED LNEIEY |
| 分子量 | 77.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MAMDC2蛋白的假设参考文献示例(仅供参考，实际文献需通过学术数据库核实)：
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1. **文献名称**：*Structural characterization and functional analysis of recombinant human MAMDC2 protein*
**作者**：Chen et al. (2021)
**摘要**：本研究成功表达并纯化了重组人MAMDC2蛋白，通过X射线晶体学解析其三维结构，揭示了其MAM结构域在细胞粘附和信号传导中的潜在作用。
2. **文献名称**：*MAMDC2 modulates inflammatory responses in macrophages via TLR4 signaling pathway*
**作者**：Wang et al. (2019)
**摘要**：发现重组人MAMDC2蛋白通过调控TLR4通路影响巨噬细胞炎症因子释放，提示其在免疫调控中的新功能。
3. **文献名称**：*MAMDC2 overexpression promotes tumor cell migration in breast cancer*
**作者**：Gupta et al. (2020)
**摘要**：实验表明，重组MAMDC2蛋白在乳腺癌细胞中高表达，并通过激活整合素信号增强肿瘤细胞迁移能力，或成为癌症治疗的潜在靶点。
4. **文献名称**：*Recombinant MAMDC2 binds to extracellular matrix proteins and supports neuronal adhesion*
**作者**：Park et al. (2018)
**摘要**：体外实验证实，重组MAMDC2蛋白能与层粘连蛋白(laminin)结合，促进神经元细胞黏附，暗示其在神经发育中的作用。
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**注意**：以上为模拟示例，MAMDC2蛋白的实际研究可能较少，建议在PubMed、Google Scholar等平台以关键词“MAMDC2”或“MAM domain-containing protein 2”检索最新文献。若结果有限，可扩展至相关蛋白家族(如MAMDC1)或功能相似蛋白的研究。
Recombinant human MAMDC2 (MAM domain containing 2) is a protein encoded by the *MAMDC2* gene, belonging to the MAM (meprin/A5 antigen/receptor protein tyrosine phosphatase mu) domain-containing protein family. This secreted glycoprotein features multiple functional domains, including a conserved MAM domain implicated in cell adhesion and protein-protein interactions. Although its biological role is not fully understood, MAMDC2 is thought to participate in extracellular matrix organization, cell signaling, and tissue development. Emerging studies suggest its involvement in inflammatory responses, cancer progression, and fibrosis, potentially modulating pathways like TGF-β or integrin signaling.
The recombinant form is engineered using expression systems (e.g., mammalian or bacterial cells) to produce high-purity protein for functional studies. Researchers employ it to investigate its interaction partners, receptor binding, or regulatory mechanisms in diseases. Its recombinant production enables applications such as antibody development, in vitro assays, and therapeutic exploration. While MAMDC2 remains understudied compared to other MAM family members, its structural homology and tissue-specific expression patterns (e.g., in placenta, lung, or immune cells) hint at context-dependent roles in health and disease. Current research focuses on clarifying its physiological functions and validating its biomarker or therapeutic potential.
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