| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | MAB21L1 |
| Uniprot No | Q13394 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-359aa |
| 活性数据 | MIAAQAKLVY HLNKYYNEKC QARKAAIAKT IREVCKVVSD VLKEVEVQEP RFISSLNEMD NRYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL KLSDGRKRSM SLWVEFITAS GYLSARKIRS RFQTLVAQAV DKCSYRDVVK MVADTSEVKL RIRDRYVVQI TPAFKCTGIW PRSAAHWPLP HIPWPGPNRV AEVKAEGFNL LSKECHSLAG KQSSAESDAW VLQFAEAENR LQMGGCRKKC LSILKTLRDR HLELPGQPLN NYHMKTLVSY ECEKHPRESD WDESCLGDRL NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALENAAK QTWRLAREIL TNPKSLEKL |
| 分子量 | 40.9 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人MAB21L1蛋白的3-4条参考文献示例(注：以下内容为模拟虚构，仅供参考)：
1. **文献名称**：Mab21l1 is essential for embryonic eye development in mice
**作者**：Yamaguchi, T.P., et al.
**摘要**：本研究通过基因敲除实验证明，MAB21L1在小鼠胚胎视网膜形成中起关键作用，重组蛋白体外实验证实其调控神经前体细胞分化的能力。
2. **文献名称**：Structural insights into the catalytic mechanism of human MAB21L1
**作者**：Chen, L., et al.
**摘要**：通过X射线晶体学解析MAB21L1的三维结构，揭示其具备类似核酸酶的功能域，重组蛋白的活性分析支持其在DNA损伤修复中的潜在作用。
3. **文献名称**：Downregulation of MAB21L1 in hepatocellular carcinoma promotes tumor progression
**作者**：Liu, Y., et al.
**摘要**：研究发现肝癌组织中MAB21L1表达显著降低，体外添加重组MAB21L1蛋白可抑制癌细胞增殖并诱导凋亡，提示其肿瘤抑制功能。
4. **文献名称**：MAB21L1 modulates TGF-β signaling pathway during neuronal differentiation
**作者**：Smith, J., et al.
**摘要**：研究显示重组MAB21L1蛋白通过结合Smad蛋白增强TGF-β信号活性，调控干细胞向神经元分化的进程。
(注：实际文献需通过学术数据库检索确认，以上内容为假设性示例。)
MAB21L1 is a member of the mammalian MAB21 protein family, which shares homology with the *Caenorhabditis elegans* mab-21 gene critical for sensory organ development. Human MAB21L1 encodes a conserved protein featuring a Mab-21 domain, implicated in cell fate determination and signaling regulation. It is expressed in developing tissues, particularly the eyes, brain, and limbs, with essential roles in embryogenesis. Studies link MAB21L1 to retinoic acid signaling, Wnt pathway modulation, and neuroectodermal patterning, influencing cell proliferation and differentiation. Mutations in MAB21L1 are associated with congenital eye malformations (e.g., microphthalmia) and neurodevelopmental disorders, underscoring its importance in organogenesis.
Recombinant human MAB21L1 protein is engineered via heterologous expression systems (e.g., *E. coli* or mammalian cells) for functional studies. Purified using affinity tags (e.g., His-tag), it enables in vitro analyses of protein interactions, post-translational modifications, and structural properties. Research utilizing recombinant MAB21L1 focuses on deciphering its molecular mechanisms, including its potential as a transcriptional co-regulator or adaptor protein in developmental pathways. Its role in disease models, particularly ocular and neurological defects, highlights therapeutic relevance. Recombinant MAB21L1 serves as a vital tool for elucidating developmental biology and identifying targets for genetic disorders.
×
