| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LYZL4 |
| Uniprot No | Q96KX0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-146aa |
| 活性数据 | MKASVVLSLLGYLVVPSGAYILGRCTVAKKLHDGGLDYFEGYSLENWVCLAYFESKFNPMAIYENTREGYTGFGLFQMRGSDWCGDHGRNRCHMSCSALLNPNLEKTIKCAKTIVKGKEGMGAWPTWSRYCQYSDTLARWLDGCKL |
| 分子量 | 42.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LYZL4蛋白的模拟参考文献示例(仅供参考，实际文献需另行检索)：
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1. **《Functional Role of Recombinant Human LYZL4 in Sperm Maturation》**
- 作者：Zhang, Y. et al.
- 摘要：研究通过哺乳动物细胞表达系统成功制备重组LYZL4蛋白，证实其在体外可增强精子活力并参与精子顶体反应，提示其在男性生殖系统中的潜在作用。
2. **《Structural Characterization and Enzymatic Activity of Recombinant LYZL4》**
- 作者：Liu, X. & Chen, W.
- 摘要：利用X射线晶体学解析LYZL4蛋白的三维结构，并发现其具备溶菌酶样水解酶活性，可能通过分解细菌细胞壁发挥先天性免疫功能。
3. **《LYZL4 as a Biomarker for Endometrial Receptivity in IVF Cycles》**
- 作者：Wang, L. et al.
- 摘要：通过检测子宫内膜分泌液中的重组LYZL4蛋白水平，探讨其与胚胎着床率的相关性，为辅助生殖技术提供潜在生物标志物。
4. **《Recombinant LYZL4 Protein Inhibits Bacterial Biofilm Formation》**
- 作者：Kim, S. et al.
- 摘要：体外实验显示，重组LYZL4蛋白可显著抑制革兰氏阳性菌(如金黄色葡萄球菌)的生物膜形成，暗示其作为新型抗菌剂的开发价值。
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提示：以上内容为假设性文献，实际研究中建议通过PubMed、Web of Science等平台检索具体论文。
Recombinant human LYZL4 protein is a genetically engineered form of the Lysozyme-like 4 (LYZL4) protein, a member of the lysozyme superfamily, which is evolutionarily conserved for its potential enzymatic or antimicrobial functions. The LYZL4 gene, located on chromosome 3 in humans, encodes a protein structurally characterized by a lysozyme-like domain, suggesting possible roles in hydrolyzing bacterial cell walls or modulating immune responses. While the precise biological functions of native LYZL4 remain under investigation, studies associate it with male reproductive health, particularly spermatogenesis, as it is highly expressed in the testis and localizes to spermatozoa. Dysregulation of LYZL4 has been linked to subfertility, implying its involvement in sperm maturation or fertilization.
The recombinant version is typically produced in heterologous expression systems (e.g., E. coli or mammalian cells) to ensure high purity and activity for experimental use. This enables researchers to explore its biochemical properties, substrate specificity, and interaction partners in vitro. Emerging evidence also hints at broader roles in innate immunity or mucosal defense, akin to other lysozyme family members, though mechanistic insights are limited. Recombinant LYZL4 serves as a critical tool for elucidating its physiological relevance, potential therapeutic applications in reproductive disorders, or as an antimicrobial agent. However, further studies are needed to define its enzymatic activity, regulatory pathways, and clinical implications conclusively.
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