| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LUZP1 |
| Uniprot No | Q86V48 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1026aa |
| 活性数据 | MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPSSSKSEGKKSREQPSVLSRYPPAAQEHSKAWKGTSKPGTESGLKGKVEKTTRTFSDTTHGSVPSDPLGRADKASDTSSETVFGKRGHVLGNGSQVTQAANSGCSKAIGALASSRRSSSEGLSKGKKAANGLEADNSCPNSKAPVLSKYPYSCRSQENILQGFSTSHKEGVNQPAAVVMEDSSPHEALRCRVIKSSGREKPDSDDDLDIASLVTAKLVNTTITPEPEPKPQPNSREKAKTRGAPRTSLFENDKDAGMENESVKSVRASTNTMELPDTNGAGVKSQRPFSPREALRSRAIIKPVIVDKDVKKIMGGSGTETTLEKQKPVSKPGPNKVTSSITIYPSDSSSPRAAPGEALRERHTSTSNIQVGLAELTSVSNHVSSPFELSIHKHDITLQLAEAERMADGPLKNRPETVVSRSSIIIKPSDPVERNSHAPPAETIRWKSHSAPSEVGFSDARHVTVRNAWKSRRDLKSLEDPPTRIGKNVESTNSNAYTQRSSTDFSELEQPRSCLFEQGTRRVGPSSGDAPEPSSRRTQSSLTVSEVLTRRNRVGDTITVAAWNHSASMSS |
| 分子量 | 141 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LUZP1蛋白的参考文献示例(注：部分内容为虚构示例，实际文献需通过数据库核实)：
1. **文献名称**: *LUZP1 regulates cell polarity and migration in cancer metastasis*
**作者**: Smith, J. et al. (2020)
**摘要**: 研究利用重组人LUZP1蛋白，发现其通过调控微管稳定性影响癌细胞极性和迁移，可能与肿瘤转移相关。
2. **文献名称**: *Structural insights into LUZP1 interaction with the cytoskeletal network*
**作者**: Chen, L. et al. (2018)
**摘要**: 通过重组蛋白纯化和X射线晶体学分析，揭示LUZP1与肌动蛋白结合的结构基础，暗示其在细胞骨架重塑中的作用。
3. **文献名称**: *LUZP1 deficiency disrupts neural tube closure in mouse models*
**作者**: Johnson, R. et al. (2021)
**摘要**: 研究重组人LUZP1蛋白在体外神经元分化中的功能，表明其缺失导致神经管闭合异常，提示胚胎发育中的关键作用。
4. **文献名称**: *LUZP1 as a potential biomarker in glioblastoma progression*
**作者**: Patel, S. et al. (2019)
**摘要**: 利用重组LUZP1进行体外实验，发现其表达水平与胶质母细胞瘤侵袭性正相关，可能作为治疗靶点。
建议通过 **PubMed** 或 **Web of Science** 以“LUZP1 recombinant protein”为关键词检索最新文献，获取真实研究数据。
**Background of Recombinant Human LUZP1 Protein**
LUZP1 (leucine zipper protein 1) is a vertebrate-specific protein characterized by a conserved leucine zipper domain, implicated in cytoskeletal organization, cell division, and early embryonic development. It localizes to centrosomes, actin-rich structures, and cellular junctions, suggesting roles in maintaining cell architecture and polarity. LUZP1 interacts with key cytoskeletal regulators, including components of the microtubule and actin networks, and modulates pathways like Hedgehog signaling. Dysregulation of LUZP1 has been linked to neurodevelopmental disorders, cardiomyopathies, and cancers, highlighting its functional importance.
Recombinant human LUZP1 protein is engineered via heterologous expression systems (e.g., *E. coli* or mammalian cells), enabling high-purity production for research applications. It serves as a critical tool for *in vitro* studies, such as deciphering LUZP1’s molecular interactions, structural properties, and regulatory mechanisms. Researchers utilize it to explore its role in cellular processes, screen for binding partners, and model disease-associated mutations. Additionally, recombinant LUZP1 aids in developing assays for drug discovery targeting LUZP1-related pathologies. Its study provides insights into developmental biology and potential therapeutic strategies for LUZP1-linked disorders.
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