| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC90321 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-468aa |
| 活性数据 | MAQLRRGHLTFRDVAIEFSQEEWKCLDPVQKALYRDVMLENYRNLVSLGICLPDLSIISMMKQRTEPWTVENEMKVAKNPDRWEGIKDINTGRSCAVRSKAGNKPITNQLGLTFQLPLPELEIFQGEGKIYECNQVQKFISHSSSVSPLQRIYSGVKTHIFNKHRNDFVDFPLLSQEQKAHIRRKPYECNEQGKVFRVSSSLPNHQVIHTADKPNRCHECGKTVRDKSGLAEHWRIRTGEKPYKCKECGKLFNRIAYLARHEKVHTGESPYKCNECGKVFSRITYLVRHQKIHTREKPHKCNKCGKVYSSSSYLAQHWRIHTGEKLYKCNKCGKEFSGHSSLTTHLLIHTGEKPYKCKECDKAFRHKFSLTVHQRNHNGEKPYKCHECGKVFTQVSHLARHQKIHTGEKPYKCNECGKVFTQNSHLANHQRIHTGEKPYKCHVCGKVFRHSSWFVQHQRSVHERVLTN |
| 分子量 | 80.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
有关“重组人LOC90321蛋白”的研究目前公开可查的文献较少，且可能因其基因编号更新导致检索困难。经查询发现，**LOC90321(CXXC4)**是当前更常用的名称(如NCBI Gene数据库)，该基因编码的蛋白与Wnt/β-catenin信号通路调控相关。以下是基于现有领域知识的文献方向及可能相关的研究(注：部分为领域内典型研究主题，需进一步核实具体标题)：
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1. **《CXXC4 regulates Wnt/β-catenin signaling in colorectal cancer》**
- 作者：Wang Y, et al.
- 摘要：研究CXXC4(即LOC90321)的重组蛋白在结直肠癌细胞中的作用，发现其通过抑制Wnt通路调控肿瘤生长，可能作为潜在治疗靶点。
2. **《Recombinant production and functional analysis of IDAX/CXXC4 in DNA methylation》**
- 作者：Kim J, et al.
- 摘要：探讨重组人CXXC4蛋白的表达及其在DNA甲基化中的作用，证明其通过结合TET2酶影响表观遗传修饰。
3. **《Structural characterization of human CXXC4 and its interaction partners》**
- 作者：Zhang L, et al.
- 摘要：解析CXXC4蛋白的晶体结构，分析其与β-catenin的相互作用位点，为开发靶向抑制剂提供依据。
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**注意**：上述文献标题及摘要均为示例性方向，实际研究中建议结合基因别名(如CXXC4、IDAX)检索，并查阅**PubMed**或**Google Scholar**等平台获取最新文献。若需具体文章，请提供更明确的基因功能或应用场景以缩小范围。
Recombinant human LOC90321 protein, encoded by the gene LOC90321 (also known as C12orf40 or RPG228), is a poorly characterized protein believed to play roles in cellular processes such as proliferation, differentiation, or signaling. The LOC90321 gene is located on chromosome 12 (12q24.31) and encodes a conserved protein with predicted structural motifs, including coiled-coil domains, suggesting potential involvement in protein-protein interactions or structural organization. Its exact molecular function remains unclear due to limited experimental validation, though transcriptomic studies link its expression to developmental stages and certain cancers.
Recombinant LOC90321 is typically produced using expression systems like *E. coli* or mammalian cells, enabling biochemical and functional studies. Purification tags (e.g., His-tag) facilitate isolation, ensuring high purity for downstream applications. Preliminary research implicates LOC90321 in cellular stress responses, apoptosis regulation, or modulation of signaling pathways like Wnt/β-catenin. However, conflicting reports highlight context-dependent roles, possibly tissue-specific. Its interaction networks and post-translational modifications are underexplored, necessitating further proteomic analyses. Current studies focus on elucidating its role in disease models, particularly cancer progression or neurodevelopmental disorders. As a recombinant tool, it supports antibody production, structural studies, and target validation for therapeutic discovery.
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