| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | LOC388503 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-363aa |
| 活性数据 | MPVRTLFPESWLWRKFTLPKSKSGISHYPISVKVPDSITTWQFVVVSLKAGQGLCVSDPFELTVMKSFFVDLKLPSSVIRNEQVQIQAMLYNFRDRQAKVRVEFPHKETLCSASKPGAPSHQAGVQIQQTSYSIVLEPQGQTQTKLVPRQEFLNMVPDTEAEVFISVQGYTQMLTHRSSDGTYHTSKGNPGSTWLTSYVFRVFALAYSMMTTQVLSLSSLCDMANWIIIDRQAEDGHFLEKGPVVMTSMQDGYQGSEEDVSLTALVLIALNEGKELCRQKNLMASIERARGFLERKLPDIQTTFAVAIASYALALANSSQANDCLDSFASPSGCGMLLNQPQSWSGEGVISNPAMCYSSLSVS |
| 分子量 | 66.88 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人LOC388503蛋白(或别名FAM84B)的假设性参考文献示例，实际文献需通过学术数据库验证：
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1. **文献名称**：*FAM84B promotes colorectal cancer progression by regulating β-catenin signaling*
**作者**：Zhang Y, et al.
**摘要**：本研究通过重组人FAM84B蛋白实验，发现其过表达激活Wnt/β-catenin通路，促进结直肠癌细胞增殖和迁移，提示其作为潜在致癌靶点。
2. **文献名称**：*Structural and functional characterization of recombinant human LOC388503 protein*
**作者**：Chen X, et al.
**摘要**：首次报道重组LOC388503蛋白的晶体结构，揭示其与肿瘤相关蛋白的结合位点，为功能机制及药物开发提供结构基础。
3. **文献名称**：*LOC388503 enhances prostate cancer cell invasion via EGFR pathway activation*
**作者**：Wang H, et al.
**摘要**：通过重组蛋白处理实验，发现LOC388503通过上调EGFR磷酸化促进前列腺癌细胞侵袭，表明其在前列腺癌转移中的作用。
4. **文献名称**：*Interaction network analysis of FAM84B in pancreatic cancer*
**作者**：Li R, et al.
**摘要**：利用重组FAM84B蛋白进行蛋白质互作组分析，识别其与多个肿瘤相关蛋白的相互作用，提示其在胰腺癌中的多功能调控角色。
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**注意**：以上为基于FAM84B/LOC388503相关研究方向的假设性示例，实际文献需查阅NCBI PubMed或Google Scholar，使用关键词“FAM84B”“recombinant”“cancer”等进一步检索确认。
Recombinant human LOC388503 protein is a product of the LOC388503 gene, which encodes a hypothetical protein with limited functional characterization in current scientific literature. The gene is located on chromosome 1 and is predicted to produce a protein with unknown structural motifs and biochemical properties, though bioinformatic analyses suggest potential involvement in cellular processes such as signal transduction or metabolic regulation. Recombinant expression systems (e.g., E. coli, mammalian cells) are employed to produce this protein for experimental studies, enabling researchers to investigate its tertiary structure, post-translational modifications, and potential physiological roles. Preliminary studies hint at possible associations with cellular stress responses, though validation in disease models remains sparse. The protein’s low sequence homology with well-characterized proteins complicates functional prediction, necessitating empirical investigations using techniques like protein-protein interaction screening, knock-out models, or antibody-based localization. Current research focuses on unraveling its molecular interactions and potential relevance to pathologies, including cancer or inflammatory conditions, where altered expression patterns have been sporadically observed. Despite its enigmatic nature, LOC388503 represents an emerging target for exploratory proteomics and functional genomics, with recombinant versions serving as critical tools for mechanistic studies. Further characterization may clarify its role in cellular homeostasis or disease pathways, potentially informing therapeutic discovery efforts.
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