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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1QTNF3 |
| Uniprot No | Q9BXJ4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 23-246aa |
| 氨基酸序列 | QDEYMESPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIGNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK |
| 预测分子量 | 28.2kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于C1QTNF3重组蛋白的3篇示例参考文献(注：文献信息为模拟示例，实际文献需根据具体数据库检索确认)：
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1. **文献名称**：*Recombinant C1QTNF3 modulates adipocyte differentiation via AMPK signaling*
**作者**：Zhang Y, et al.
**摘要**：研究通过大肠杆菌表达系统制备重组C1QTNF3蛋白，发现其能激活AMPK通路，促进前脂肪细胞分化，提示其在脂代谢调控中的潜在作用。
2. **文献名称**：*Structural and functional characterization of recombinant human C1QTNF3*
**作者**：Lee S, et al.
**摘要**：解析了重组C1QTNF3的晶体结构，并通过体外实验证明其通过结合TGF-β受体抑制成骨细胞凋亡，为骨骼疾病治疗提供新靶点。
3. **文献名称**：*C1QTNF3 as a novel biomarker in colorectal cancer: insights from recombinant protein-based assays*
**作者**：Wang X, et al.
**摘要**：利用重组C1QTNF3建立ELISA检测方法，发现其在结直肠癌患者血清中显著高表达，且与肿瘤进展和预后不良相关。
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如需具体文献，建议通过PubMed或Google Scholar以关键词 **"C1QTNF3 recombinant protein"** 或 **"C1QTNF3 function"** 检索，并筛选实验性研究论文。
C1QTNF3. also known as CTRP3 (C1q/tumor necrosis factor-related protein 3), is a secretory glycoprotein belonging to the C1q/TNF superfamily. It shares structural homology with adiponectin, featuring a conserved C-terminal C1q-like globular domain and a variable N-terminal collagen-like domain. This protein is broadly expressed in adipose tissue, skeletal muscle, and the cardiovascular system, playing multifaceted roles in metabolic regulation, inflammation, and tissue remodeling.
Functionally, C1QTNF3 acts as an adipokine with endocrine and paracrine signaling properties. It enhances insulin sensitivity by activating AMP-activated protein kinase (AMPK) and suppressing gluconeogenesis in the liver. Studies highlight its anti-inflammatory effects through modulation of NF-κB signaling and inhibition of pro-inflammatory cytokines like TNF-α and IL-6. Additionally, it promotes angiogenesis and endothelial cell migration via adiponectin receptor binding, while paradoxically exhibiting both tumor-suppressive and tumor-promoting activities in different cancer contexts.
Emerging evidence links C1QTNF3 dysregulation to metabolic disorders, cardiovascular diseases, and cancer progression. Reduced circulating levels correlate with obesity, type 2 diabetes, and atherosclerosis, suggesting therapeutic potential. In oncology, its role remains context-dependent, showing anti-tumor effects in glioblastoma but pro-metastatic activity in osteosarcoma.
Recombinant C1QTNF3 protein, typically produced in mammalian or bacterial expression systems, enables functional studies and therapeutic exploration. Its purified form retains bioactivity for investigating signaling pathways and evaluating preclinical efficacy in metabolic syndrome, inflammatory conditions, and cancer models. Current research focuses on optimizing its stability and delivery mechanisms for potential clinical applications.
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