| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KRTAP4-5 |
| Uniprot No | Q9BYR2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-181aa |
| 活性数据 | MVSSCCGSVSSEQSCGLENCCRPSCCQTTCCRTTCCRPSCCKPQCCQSVCYQPTCCHPSCCISSCCRPYCCESSCCRPCCCQTTCCRTTCCRTTCCCPSCCVSSCCRPQCCQSVCCQPTCCRPSCCISSCCHPSCCESSCCRPCCCVRPVCGRVSCHTTCYRPTCVISTCPRPLCCASSCC |
| 分子量 | 20 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KRTAP4-5蛋白的示例参考文献(注：文献为示例，实际研究可能有限，需根据实际数据库补充)：
1. **《Cloning and characterization of human KRTAP4-5 as a hair keratin-associated protein》**
- 作者：Smith A, et al.
- 摘要：研究克隆了人KRTAP4-5基因并在大肠杆菌中成功表达重组蛋白，发现其参与毛发角蛋白交联，可能与发丝力学性能相关。
2. **《Expression profiling of KRTAP4-5 in human hair follicles and its interaction with keratin polymers》**
- 作者：Li J, et al.
- 摘要：通过免疫组化及体外重组蛋白实验，发现KRTAP4-5在毛囊皮质层高表达，可能通过与角蛋白K85结合调控毛发结构。
3. **《A novel mutation in KRTAP4-5 linked to hereditary hair fragility syndrome》**
- 作者：Wang Y, et al.
- 摘要：报道了KRTAP4-5基因突变导致重组蛋白结构异常，并证明其与家族性毛发脆弱性疾病的相关性。
4. **《Structural analysis of recombinant human KRTAP4-5 and its role in trichocyte cytoskeleton assembly》**
- 作者：Chen R, et al.
- 摘要：利用X射线晶体学解析重组KRTAP4-5结构，揭示其通过二硫键稳定角蛋白基质的功能，为毛发疾病治疗提供靶点。
**提示**：上述内容为基于KRTAP家族研究的模拟文献，实际文献需通过PubMed、Web of Science等平台检索。若研究较少，可扩大关键词(如“keratin-associated proteins”或“KRTAP4”)或关注功能相似蛋白(如KRTAP4-4/4-12)。
Recombinant human KRTAP4-5 protein is a genetically engineered form of the keratin-associated protein 4-5. a member of the KRTAP family involved in the structural integrity of hair and skin. KRTAPs are cysteine-rich proteins that interact with keratins to form cross-linked networks, contributing to the mechanical strength and elasticity of epithelial tissues. KRTAP4-5. located within the human hair follicle cortex, is thought to play a role in regulating hair fiber formation and texture through disulfide bond formation with keratins. Variations in the KRTAP4-5 gene have been associated with differences in hair traits, such as curliness and thickness. Recombinant production of KRTAP4-5 typically involves expression in bacterial (e.g., E. coli) or mammalian systems, followed by purification to study its biochemical properties and interactions. Research on this protein aims to elucidate its role in hair biology, potential links to hereditary hair disorders, and applications in cosmetic or biomedical industries, such as developing hair-care formulations or biomaterials mimicking natural keratin structures. Its study also provides insights into epithelial tissue resilience and disease mechanisms.
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