| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1467 |
| Uniprot No | A2RU67 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-622aa |
| 活性数据 | MATVLSRALKLPGKKSPDLGEYDPLTQADSDESEDDLVLNLQKNGGVKNGKSPLGEAPEPDSDAEVAEAAKPHLSEVTTEGYPSEPLGGLEQKAASSLVSYVRTSVFLLTLGISMILVLLCAFLIPCPPRDLHSTWSRHLGSQGGGDLSPLELADVNGDGLRDVLLSFVMSRNGSAVGVSRPAANLVCLSGMNGSTLWSSLLPEEARDITCLELMPGSLAETICLVTGTHKMLSAFNATSGKAIWTLNPNYLSNGTLAAPVVVLPDLDEDGVRDLVVLAIGELQPDLCFLLVSGRTGNPVGRPVKYNIVGVGNLIGPQVYITTNGAVYILFGFGNIQAVALRDIFVQAQNRDSSPPSLQIEEPEWEKRRSINLSELIDVYSDGVELLQMVKAPDSNCSNLLITTRQSLVLLRGQNLTPYWALRLQGLRSQPTPGYFTDDQTLDFLLQIQDGVGMKKMMVVDGDSGSIVWSYRAPCHMKETPATSAVTSDQKSVFLFWAEGLSAASPNSDIILGTEPPSLHHLYLLHPAFPSILLDLANTTGTVTASEVGINDLWKDAFYVTRTTGPSSEGHPAALVVSKLSLRWALMEGQMAQLQESTPKIGRGELRRFLSRIKFVEAPYEI |
| 分子量 | 93.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3-4条关于重组人KIAA1467蛋白(KIAA1467/JCAD)的假想参考文献范例(注意：以下内容为模拟，实际文献需根据真实数据库查询)：
1. **文献名称**：*KIAA1467/JCAD regulates endothelial cell migration and atherosclerosis through RhoA/ROCK signaling*
**作者**：Zhang Y, et al.
**摘要**：本研究阐明了重组人KIAA1467蛋白在调控血管内皮细胞迁移中的功能，发现其通过激活RhoA/ROCK通路促进动脉粥样硬化斑块形成。
2. **文献名称**：*Structural and functional characterization of the JCAD protein interaction network in cardiac disease*
**作者**：Wang L, et al.
**摘要**：通过重组蛋白表达和质谱分析，揭示了KIAA1467与心肌细胞中β-catenin等蛋白的相互作用，提示其在心脏疾病中的潜在调控作用。
3. **文献名称**：*JCAD promotes tumor angiogenesis via enhancing VEGFR2 stability in colorectal cancer*
**作者**：Chen X, et al.
**摘要**：发现重组KIAA1467蛋白可结合VEGFR2并抑制其泛素化降解，从而增强肿瘤血管生成，为癌症治疗提供新靶点。
4. **文献名称**：*A novel role of KIAA1467 in maintaining endothelial barrier integrity under shear stress*
**作者**：Tanaka K, et al.
**摘要**：利用重组蛋白体外实验证明，KIAA1467通过稳定VE-cadherin连接复合物，保护内皮屏障免受血流剪切力损伤。
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**说明**：以上为模拟文献，真实文献需通过PubMed、Google Scholar等平台以“KIAA1467”或“JCAD”为关键词检索，近年研究多集中在其与心血管疾病(如冠心病)、细胞连接和肿瘤微环境的关联。
KIAA1467. also known as DENND6A or C14orf148. is a human protein encoded by the KIAA1467 gene located on chromosome 14. Its biological functions remain incompletely characterized, but emerging studies suggest roles in intracellular trafficking, cytoskeletal organization, and cellular signaling pathways. Structural analyses reveal conserved domains, including a DENN (differentially expressed in neoplastic versus normal cells) module, which typically regulates guanine nucleotide exchange factors (GEFs) involved in membrane trafficking. KIAA1467 is ubiquitously expressed across tissues, with higher levels observed in the brain, hinting at potential neural functions. Recent research links it to neurodevelopmental processes and diseases, including autism spectrum disorders and intellectual disabilities.
Recombinant human KIAA1467 protein is generated using expression systems like E. coli or mammalian cells, enabling functional and biochemical studies. Its recombinant form facilitates investigations into protein-protein interactions, post-translational modifications, and mechanistic pathways. Proteomic studies identify binding partners such as Rab GTPases, suggesting involvement in vesicle transport regulation. Additionally, variants in KIAA1467 have been associated with cancer progression and metabolic disorders, making it a potential therapeutic target. Despite progress, detailed molecular mechanisms and disease-relevant pathways remain under exploration. Production of recombinant KIAA1467 accelerates antibody development, structural studies, and functional assays to elucidate its physiological and pathological significance.
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