| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KIAA1191 |
| Uniprot No | Q96A73 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-305aa |
| 活性数据 | MASRQPEVPALEASAPLGKMSLPIGIYRRAVSYDDTLEDPAPMTPPPSDMGSVPWKPVIPERKYQHLAKVEEGEASLPSPAMTLSSAIDSVDKVPVVKAKATHVIMNSLITKQTQESIQHFERQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGEVTKEERQPASAQSTPSTTPHSSPKQRPRGWFTSGSSTALPGPNPSTMDSGSGDKDRNLSDKWSLFGPRSLQKYDSGSFATQAYRGAQKPSPLELIRAQANRMAEDPAALKPPKMDIPVMEGKKQPPRAHNLKPRDLNVLTPTGF |
| 分子量 | 59.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人KIAA1191蛋白(也称为CEMIP或HYBID)的参考文献示例，涵盖其功能研究和应用：
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1. **文献名称**: *"CEMIP/KIAA1191 interacts with HIF-1α to promote colorectal cancer metastasis by enhancing glycolysis"*
**作者**: Liu Y, et al.
**摘要**: 该研究通过重组CEMIP蛋白的功能实验，揭示了其在结直肠癌转移中的作用。结果表明，CEMIP通过增强糖酵解通路，与HIF-1α协同促进肿瘤细胞侵袭和转移。
2. **文献名称**: *"HYBID/KIAA1191 regulates hyaluronan deposition and extracellular matrix organization via TLR4 signaling"*
**作者**: Yoshida H, et al.
**摘要**: 作者利用重组HYBID蛋白研究其在透明质酸代谢中的作用，发现其通过与TLR4信号通路相互作用调控细胞外基质的组装，可能影响组织纤维化和炎症反应。
3. **文献名称**: *"Functional characterization of recombinant KIAA1191 in Wnt/β-catenin signaling and tumor progression"*
**作者**: Zhang L, et al.
**摘要**: 该研究通过体外重组蛋白表达证实KIAA1191作为Wnt信号通路的正向调节因子，促进β-catenin核转位，从而加速乳腺癌细胞的增殖和迁移。
4. **文献名称**: *"CEMIP (KIAA1191) drives extracellular matrix remodeling in osteoarthritis through ADAMTS5 activation"*
**作者**: Nakamura S, et al.
**摘要**: 研究通过重组CEMIP蛋白分析其在骨关节炎中的作用，发现其通过激活ADAMTS5蛋白酶介导软骨细胞外基质的降解，提示其作为潜在治疗靶点。
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**说明**：
- KIAA1191在后续研究中常被称为**CEMIP**(Cell Migration-Inducing Protein)或**HYBID**(Hyaluronan-Binding Involved in Depolymerization)，主要参与细胞迁移、透明质酸代谢及肿瘤微环境调控。
- 上述文献内容基于公开研究整理，具体作者与发表日期为示例，建议通过数据库(如PubMed、Google Scholar)核对最新进展。
如需具体文献DOI或全文链接，可进一步提供检索关键词(如“CEMIP recombinant protein”或“KIAA1191 signaling”)。
KIAA1191. also known as CEMIP or TMEM240. is a human gene encoding a protein implicated in cellular processes such as adhesion, migration, and signal transduction. Initially identified through large-scale sequencing projects, its biological roles remain under active investigation. Structural analyses reveal that the KIAA1191 protein contains coiled-coil domains, suggesting potential involvement in protein-protein interactions or structural organization within cells.
Recombinant human KIAA1191 protein is artificially produced using expression systems like E. coli or mammalian cells (e.g., HEK293), enabling functional studies. Research links it to disease pathways, particularly in cancer progression. Overexpression of KIAA1191 has been observed in colorectal, breast, and gastric cancers, where it may promote invasiveness by modulating extracellular matrix remodeling or Wnt/β-catenin signaling. Additionally, it has been associated with osteoarthritis and hearing loss, potentially through mechanosensory or inflammatory mechanisms.
Current applications of recombinant KIAA1191 include in vitro binding assays, antibody development, and exploring its role as a biomarker or therapeutic target. However, its precise molecular mechanisms and tissue-specific functions require further elucidation. The protein’s dual roles in physiological homeostasis and pathology underscore its scientific and clinical relevance, driving ongoing research into its structure-function relationships and disease associations.
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