| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL17R |
| Uniprot No | Q96F46 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 33-132aa |
| 氨基酸序列 | LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFL |
| 分子量 | 36.74 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人IL-17R蛋白的假设参考文献(基于领域研究常规)：
1. **文献名称**：Structural and functional characterization of recombinant human IL-17 receptor A
**作者**：Smith J, et al.
**摘要**：解析了重组人IL-17RA胞外域的晶体结构，阐明其与IL-17A的结合机制，为开发自身免疫病抑制剂提供结构基础。
2. **文献名称**：Expression and purification of recombinant human IL-17RC in mammalian cells
**作者**：Wang L, et al.
**摘要**：优化了哺乳动物细胞中重组IL-17RC蛋白的表达与纯化流程，并验证其在体外模型中对IL-17信号通路的调控功能。
3. **文献名称**：Recombinant IL-17 receptor B fusion protein ameliorates psoriasis-like skin inflammation
**作者**：Chen X, et al.
**摘要**：开发重组IL-17RB-Fc融合蛋白，通过阻断IL-17信号显著减轻小鼠银屑病模型的炎症反应。
4. **文献名称**：Functional crosstalk between IL-17 receptor and TLR4 in epithelial cells
**作者**：Kim H, et al.
**摘要**：利用重组IL-17R蛋白揭示IL-17受体与TLR4的协同作用机制，推动对炎症性肠病中免疫通路交互的理解。
注：以上文献为示例，实际研究中需检索具体数据库(如PubMed)获取真实参考文献。
Recombinant human IL-17 receptor (IL-17R) protein is a biologically active form of the interleukin-17 receptor, a key mediator in inflammatory and autoimmune signaling. IL-17R belongs to the Type I transmembrane receptor family, primarily expressed on epithelial, endothelial, and immune cells. Structurally, it contains extracellular fibronectin III-like domains critical for ligand binding, a single transmembrane helix, and a conserved cytoplasmic SEF/IL-17R (SEFIR) domain essential for downstream signaling.
IL-17R interacts with pro-inflammatory cytokines IL-17A and IL-17F, secreted by Th17 cells, to activate pathways like NF-κB and MAPK. This triggers the production of chemokines (e.g., CXCL1. CXCL8) and antimicrobial peptides, amplifying neutrophil recruitment and tissue inflammation. Dysregulated IL-17/IL-17R signaling is implicated in psoriasis, rheumatoid arthritis, and inflammatory bowel disease.
Recombinant IL-17R, often produced in mammalian or insect systems, serves as a research tool to study receptor-ligand interactions, screen inhibitors, or develop therapeutic strategies. Soluble IL-17R variants (e.g., fusion proteins like IL-17RC-Fc) act as decoy receptors to neutralize excess IL-17. offering potential in autoimmune disease treatment. Its therapeutic relevance is underscored by FDA-approved IL-17/IL-17R-targeting biologics, such as secukinumab and brodalumab, highlighting its translational significance in immunology and drug development.
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