关键信息
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基因名
IGFBP-5
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简介
The IGFBP-5 protein regulates insulin-like growth factor (IGF) and extends its lifespan. It can inhibit or stimulate the growth-promoting effect of IGF, showing its dual regulatory function. IGFBP-5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGFBP-5 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
- 应用
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别名
Insulin-Like Growth Factor-Binding Protein 5; IBP-5; IGF-Binding Protein 5; IGFBP-5; IGFBP5; IBP5
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24593
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表达区间
L21-E272
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氨基酸序列
LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
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蛋白长度
Full Length of Mature Protein
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分子量
32-45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Insulin-like growth factor binding protein 5 (IGFBP-5) is a member of the IGFBP family that plays a crucial role in mediating the effects of insulin-like growth factors (IGFs) on cellular processes such as growth, differentiation, and apoptosis. Elevated levels of IGFBP-5 have been associated with various physiological and pathological conditions, including cancer progression, tissue regeneration, and age-related diseases. Its multifunctional properties not only regulate IGF availability but also can exert IGF-independent effects by interacting with other molecules in the extracellular matrix and cell surfaces. The recombinant production of IGFBP-5 holds significant potential for therapeutic applications, as it can be utilized to modulate IGF signaling pathways and influence cell behavior in various contexts. Research into IGFBP-5 recombinant protein focuses on understanding its structure-function relationships, optimizing production methods, and elucidating its biological roles in different tissues. As such, studying IGFBP-5 at a molecular level is essential for developing targeted therapies aimed at controlling IGF-related disorders and enhancing tissue repair mechanisms. Additionally, the exploration of IGFBP-5 as a biomarker for certain diseases could provide valuable insights for early diagnosis and treatment strategies. Overall, the investigation of IGFBP-5 recombinant proteins contributes to a broader understanding of IGF signaling dynamics and their implications in health and disease.
