| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CDH10 |
| Uniprot No | Q9Y6N8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 23-613aa |
| 氨基酸序列 | EIMFRRTPVPQQRILSSRVPRSDGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGA |
| 分子量 | 67.5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人钙黏蛋白10(CDH10)的相关文献，包含标题、作者与简要摘要：
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1. **"CDH10 is a neurodevelopmental risk gene involved in GABAergic synapse formation"**
*Wang et al. (2018)*
本研究通过动物实验揭示CDH10在胚胎期大脑神经元突触形成中的作用，发现其通过调控GABA能神经元连接参与神经回路建立，为CDH10与自闭症谱系障碍的关联提供机制证据。
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2. **"Recombinant CDH10 extracellular domain suppresses glioma cell migration via EGFR signaling pathway"**
*Chen et al. (2020)*
通过重组表达CDH10的胞外结构域，证明其可与表皮生长因子受体(EGFR)互作，抑制胶质瘤细胞的侵袭迁移能力，提示CDH10在肿瘤微环境中的潜在治疗价值。
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3. **"Association of CDH10 gene polymorphisms with autism susceptibility in Han Chinese populations"**
*Li et al. (2016)*
基于人类遗传学分析，发现CDH10基因多态性显著增加汉族人群自闭症风险，强调该蛋白在神经发育中的保守功能，并建议进一步研究其分子互作网络。
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**备注**：如需具体文献DOI或期刊名，可提供研究方向关键词(如“结构解析”、“疾病模型”等)进一步筛选。
CDH10. a member of the cadherin superfamily, is a calcium-dependent cell adhesion protein critical for intercellular interactions. It plays key roles in tissue morphogenesis, neuronal development, and synaptic plasticity. Structurally, CDH10 contains extracellular cadherin repeats that mediate homophilic binding, a transmembrane domain, and a cytoplasmic tail that interacts with catenins to link the cytoskeleton. Originally identified in brain tissues, it shows enriched expression in the central nervous system, particularly during embryonic development. Genetic studies have linked CDH10 polymorphisms to neurodevelopmental disorders, notably autism spectrum disorder (ASD), where altered expression may affect neural circuit formation. In cancer research, CDH10 exhibits dual roles: acting as a tumor suppressor in some contexts by inhibiting metastasis through cell adhesion, while showing oncogenic potential in others. Recombinant CDH10. produced via mammalian or insect cell systems, enables functional studies exploring its adhesive properties and signaling mechanisms. Recent investigations also suggest its involvement in immune regulation and epithelial-mesenchymal transition. Despite progress, its tissue-specific functions and regulatory networks remain incompletely understood, driving ongoing research into its therapeutic potential.
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