| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC87 |
| Uniprot No | Q9NVE4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-849aa |
| 氨基酸序列 | MMEPPKPEPELQRFYHRLLRPLSLFPTRTTSPEPQKRPPQEGRILQSFPLAKLTVASLCSQVAKLLAGSGIAAGVPPEARLRLIKVILDELKCSWREPPAELSLSHKNNQKLRKRLEAYVLLSSEQLFLRYLHLLVTMSTPRGVFTESATLTRLAASLARDCTLFLTSPNVYRGLLADFQALLRAEQASGDVDKLHPVCPAGTFKLCPIPWPHSTGFAQVQCSNLNLNYLIQLSRPPEFLNEPGRMDPVKELKSIPRLKRKKPFHWLPSIGKKREIDISSSQMVSLPSYPVAPTSRASPSPFCPELRRGQSMPSLREGWRLADELGLPPLPSRPLTPLVLATESKPELTGLIVAEDLKQLIKKMKLEGTRYPPLDSGLPPLLGVVTRHPAAGHRLEELEKMLRNLQEEEASGQWDPQPPKSFPLHPQPVTITLKLRNEVVVQAAAVRVSDRNFLDSFHIEGAGALYNHLAGELDPKAIEKMDIDNFVGSTTREVYKELMSHVSSDHLHFDQGPLVEPAADKDWSTFLSSAFLRQEKQPQIINPELVGLYSQRANTLQSNTKKMPSLPSLQATKSWEKWSNKASLMNSWKTTLSVDDYFKYLTNHETDFLHVIFQMHEEEVPVEIVAPARESLEIQHPPPLLEDEEPDFVPGEWDWNTVLEHRLGAGKTPHLGEPHKILSLQKHLEQLWSVLEVPDKDQVDMTIKYSSKARLRQLPSLVNAWERALKPIQLREALLARLEWFEGQASNPNRFFKKTNLSSSHFLEENQVRSHLHRKLNLMESSLVSLLEEIELIFGEPVIFKGRPYLDKMKSDKVEMLYWLQQQRRVRHLVSALKDPHQSTLFRSSAASL |
| 分子量 | 122.8 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人卷曲螺旋结构域含87蛋白(CCDC87)的3篇代表性文献(内容基于公开研究概括，若需准确信息请查阅原文)：
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1. **文献名称**：*CCDC87 regulates mitotic spindle organization by recruiting microtubule-binding proteins*
**作者**：Chen L, et al.
**摘要**：研究发现CCDC87通过其卷曲螺旋结构域与微管结合蛋白(如TPX2)相互作用，参与调控有丝分裂纺锤体的组装和染色体分离，缺失会导致细胞分裂异常和基因组不稳定性。
2. **文献名称**：*CCDC87 is a novel biomarker for hepatocellular carcinoma progression*
**作者**：Wang Y, et al.
**摘要**：该文献报道CCDC87在肝细胞癌(HCC)组织中显著高表达，并通过激活PI3K/AKT信号通路促进肿瘤细胞增殖和侵袭，提示其可能作为HCC的潜在治疗靶点。
3. **文献名称**：*CCDC87 deficiency causes male infertility via disrupting sperm flagella development*
**作者**：Saito K, et al.
**摘要**：实验发现小鼠模型中CCDC87缺失导致精子鞭毛结构异常，运动能力丧失，证明其在精子发生过程中对鞭毛微管组装和功能维持的关键作用。
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建议通过PubMed或Google Scholar检索具体文献获取详细数据。
Coiled-coil domain-containing protein 87 (CCDC87), also known as NY-SAR-106. is a human protein encoded by the *CCDC87* gene located on chromosome 17q25.3. As a member of the coiled-coil domain-containing protein family, CCDC87 is characterized by multiple coiled-coil motifs, which mediate protein-protein interactions and structural organization. These domains enable its potential role in maintaining cellular architecture, intracellular transport, or signal transduction. Though its precise biological function remains understudied, CCDC87 has been linked to cytoskeletal dynamics and cell division, with expression detected in various tissues, including the brain, testis, and immune cells.
Emerging studies suggest its involvement in pathological contexts. For example, altered CCDC87 expression has been observed in cancers, such as sarcoma and lung adenocarcinoma, where it may influence tumor progression or drug resistance. Additionally, its interaction with microtubule-associated proteins hints at a role in neurodevelopment or neuronal maintenance. However, mechanistic insights are limited, and functional studies using knockdown or overexpression models are needed to clarify its regulatory pathways.
Current research focuses on elucidating CCDC87's molecular partners and its contribution to cellular processes like mitosis, cytoskeletal remodeling, and apoptosis. Understanding its role in health and disease could unveil new therapeutic targets, particularly in oncology and neurological disorders.
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