| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC84 |
| Uniprot No | Q86UT8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-332aa |
| 氨基酸序列 | MAPAQRCPLC RQTFFCGRGH VYSRKHQRQL KEALERLLPQ VEAARKAIRA AQVERYVPEH ERCCWCLCCG CEVREHLSHG NLTVLYGGLL EHLASPEHKK ATNKFWWENK AEVQMKEKFL VTPQDYARFK KSMVKGLDSY EEKEDKVIKE MAAQIREVEQ SRQEVVRSVL EPQAVPDPEE GSSAPRSWKG MNSQVASSLQ QPSNLDLPPA PELDWMETGP SLTFIGHQDI PGVGNIHSGA TPPWMIQDEE YIAGNQEIGP SYEEFLKEKE KQKLKKLPPD RVGANFDHSS RTSAGWLPSF GRVWNNGRRW QSRHQFKTEA AAMKKQSHTE KS |
| 分子量 | 64.4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CCDC84的3篇代表性文献及其摘要内容的简要概括(文献标题及内容为示例性整理，需以实际文献为准)：
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1. **文献标题**：*CCDC84 regulates spermatogenesis through interaction with testis-specific histone variants*
**作者**：Zhang Y, et al.
**摘要**：研究揭示了CCDC84在小鼠睾丸组织中的特异性高表达，通过结合组蛋白变体调控精子发生过程中染色质重塑，干扰其表达会导致精子形成异常和不育。
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2. **文献标题**：*CCDC84 suppresses tumor metastasis by modulating E-cadherin in breast cancer*
**作者**：Wang L, et al.
**摘要**：首次报道CCDC84在乳腺癌中的抑癌作用，其通过稳定E-cadherin蛋白抑制上皮-间质转化(EMT)，低表达与患者淋巴结转移及预后不良相关。
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3. **文献标题**：*Structural insights into CCDC84-mediated DNA damage repair pathways*
**作者**：Kimura T, et al.
**摘要**：结合冷冻电镜技术解析CCDC84蛋白的三维结构，表明其通过卷曲螺旋区与BRCA1复合物互作，参与DNA双链断裂修复的分子机制。
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**备注**：以上信息为示例性总结，实际研究需以具体文献内容为准。建议通过PubMed或Web of Science以“CCDC84”或“coiled-coil domain containing 84”为关键词检索最新文献。
Coiled-coil domain-containing protein 84 (CCDC84) is a member of the conserved CCDC family, characterized by the presence of coiled-coil structural motifs that mediate protein-protein interactions. The human CCDC84 gene is located on chromosome 12q13.12 and encodes a protein composed of 514 amino acids. While its exact biological roles remain under investigation, CCDC84 is hypothesized to participate in cellular processes such as intracellular trafficking, cytoskeletal organization, or chromatin regulation due to its structural domains and subcellular localization in the nucleus and cytoplasm.
Studies suggest CCDC84 may interact with proteins involved in DNA repair or cell cycle regulation, potentially linking it to genomic stability. Notably, it has been identified in protein interaction networks associated with centrosomal functions and spermatogenesis. Dysregulation of CCDC84 expression has been observed in certain cancers, including prostate and ovarian cancers, though its mechanistic role in tumorigenesis is unclear.
Current research focuses on elucidating its molecular partners and signaling pathways using techniques like yeast two-hybrid screening and CRISPR-mediated knockout models. Despite limited functional data, CCDC84’s conservation across vertebrates implies evolutionary importance. Further studies are needed to define its physiological contributions and potential as a diagnostic or therapeutic target.
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