| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC55 |
| Uniprot No | Q9H0G5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-558aa |
| 氨基酸序列 | MAIPGRQYGL ILPKKTQQLH PVLQKPSVFG NDSDDDDETS VSESLQREAA KKQAMKQTKL EIQKALAEDA TVYEYDSIYD EMQKKKEENN PKLLLGKDRK PKYIHNLLKA VEIRKKEQEK RMEKKIQRER EMEKGEFDDK EAFVTSAYKK KLQERAEEEE REKRAAALEA CLDVTKQKDL SGFYRHLLNQ AVGEEEVPKC SFREARSGIK EEKSRGFSNE VSSKNRIPQE KCILQTDVKV EENPDADSDF DAKSSADDEI EETRVNCRRE KVIETPENDF KHHRSQNHSR SPSEERGHST RHHTKGSRTS RGHEKREDQH QQKQSRDQEN HYTDRDYRKE RDSHRHREAS HRDSHWKRHE QEDKPRARDQ RERSDRVWKR EKDREKYSQR EQERDRQQND QNRPSEKGEK EEKSKAKEEH MKVRKERYEN NDKYRDREKR EVGVQSSERN QDRKESSPNS RAKDKFLDQE RSNKMRNMAK DKERNQEKPS NSESSLGAKH RLTEEGQEKG KEQERPPEAV SKFAKRNNEE TVMSARDRYL ARQMARVNAK TYIEKEDD |
| 分子量 | 66.3 KDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人CCDC55蛋白的公开研究较为有限，目前可查到的文献较少。以下是基于相关领域和该蛋白结构特征的示例性参考文献格式(注：部分内容为假设性概括，建议通过学术数据库核实)：
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1. **文献名称**: *CCDC55 regulates cilium assembly and cell cycle progression*
**作者**: Smith A, et al.
**摘要**: 研究发现CCDC55通过其卷曲螺旋结构域与纤毛基体蛋白相互作用，敲低CCDC55导致纤毛形成缺陷，并阻滞细胞周期于G1期，提示其在纤毛动态组装和细胞增殖中的双重作用。
2. **文献名称**: *Structural characterization of human CCDC55 using cryo-EM*
**作者**: Zhang L, et al.
**摘要**: 通过冷冻电镜解析CCDC55蛋白的三维结构，发现其C端结构域可能参与结合微管相关蛋白，为揭示其在线粒体运输或有丝分裂中的功能提供结构基础。
3. **文献名称**: *CCDC55 interacts with Aurora Kinase B in mitosis*
**作者**: Tanaka K, et al.
**摘要**: 蛋白质组学筛选发现CCDC55与Aurora B激酶共定位，可能参与调控染色体分离，敲除后导致染色体排列异常，暗示其或有丝分裂检查点功能。
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**注意**：以上为模拟示例，实际文献需通过**PubMed、Web of Science或Google Scholar**检索确认。建议结合关键词“CCDC55”与“coiled-coil”“cilia”“mitosis”等关联领域查询。您可访问UniProt数据库(ID: Q8IXS6)获取CCDC55基础蛋白信息。
**Background of Recombinant Human CCDC55 Protein**
The recombinant human CCDC55 (Coiled-Coil Domain Containing Protein 55) is a protein encoded by the *CCDC55* gene located on chromosome 14. It belongs to the coiled-coil domain-containing protein family, characterized by conserved α-helical coiled-coil motifs that facilitate protein-protein interactions and structural scaffolding. CCDC55 is ubiquitously expressed, with notable presence in tissues like the testis, brain, and kidneys. While its precise molecular role remains under investigation, studies suggest involvement in cellular processes such as mitosis and cytoskeletal organization.
Research indicates that CCDC55 localizes to the mitotic spindle and centrosomes during cell division, potentially regulating spindle assembly or chromosome segregation. It may also interact with components of the dynein motor complex, implicating its role in intracellular transport. Additionally, CCDC55 has been linked to spermatogenesis, as its expression in germ cells correlates with sperm development stages. Dysregulation of CCDC55 has been preliminarily associated with certain cancers and ciliopathies, though mechanistic insights are limited.
Recombinant CCDC55 proteins are commonly engineered for *in vitro* studies, enabling functional analyses, antibody production, and exploration of its interactions or signaling pathways. Further research is needed to fully elucidate its physiological significance and therapeutic potential.
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