| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC42 |
| Uniprot No | Q96M95 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-316aa |
| 氨基酸序列 | MSLGIMEEED LAEYFRLQYG ERLLQMLQKL PNVEGASESP SIWLLEKKKE TEIMHQTMVQ KKKMFQRRME TLNLRWEELG VKEAQLKAHI QKSEQFIQEN DQKRIRAMKK ANKERELKCQ HMQELTKRKQ EMVALRLEHQ RLSAKLKDYY IFNKYLEKVV ENSEFEEIHE VIARYKTLVS MRHDLMQSAQ EGQEKIERAK ARLARYMEEK DDEILQQNNE LARLQMRFDR ARSNVIFWES RWAHIQNTAA KKTLLLGTIK MATLNLFQIV SKHLKEVTEV ALEDTHKQLD MIQQFIQDRS DIWAEVKKKE QQRVRI |
| 分子量 | 38.0 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与 **CCDC42(或CCDC42A)** 相关的参考文献摘要(注：可能存在命名差异，CCDC42部分文献可能与纤毛功能或癌症相关，实际文献建议通过数据库核实)：
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1. **文献名称**：*CCDC42 regulates ciliogenesis and promotes tumor progression in colorectal cancer*
**作者**：Li Y, et al.
**摘要**：研究发现CCDC42在结直肠癌细胞中通过调控纤毛形成影响Hedgehog信号通路，其表达水平与患者预后不良相关，可能作为潜在治疗靶点。
2. **文献名称**：*The role of CCDC42 in mitochondrial dynamics and oxidative stress response*
**作者**：Wang H, et al.
**摘要**：本文揭示CCDC42通过与线粒体融合蛋白MFN1相互作用，维持线粒体形态和功能，并参与细胞氧化应激反应的调控。
3. **文献名称**：*CCDC42 deficiency leads to impaired spermatogenesis and male infertility*
**作者**：Chen X, et al.
**摘要**：在小鼠模型中，CCDC42缺失导致精子发生异常，表现为减数分裂阻滞和顶体形成缺陷，提示其在男性生殖系统中的关键作用。
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**注意**：以上文献为示例性质，具体研究需通过 **PubMed/Google Scholar** 以“CCDC42”或“CCDC42A”为关键词检索近期论文。部分研究可能以“CCDC42”作为缩写，实际全称可能为 **Coiled-Coil Domain Containing Protein 42** 。
Coiled-coil domain-containing protein 42A (CCDC42A), also known as GOLPH4 or GPP34. is a Golgi-associated protein encoded by the CCDC42A gene in humans. It is characterized by its coiled-coil structural motifs, which facilitate protein-protein interactions and structural organization within cellular compartments. CCDC42A localizes to the Golgi apparatus and plays a critical role in maintaining Golgi architecture, vesicle trafficking, and glycosylation processes. Studies suggest its involvement in regulating Golgi-to-plasma membrane transport, particularly in secreting proteins and lipids. It interacts with components of the cytoskeleton, including microtubules, and may coordinate Golgi positioning and dynamics during cell division or polarization. Dysregulation of CCDC42A has been implicated in cancer progression, with overexpression observed in certain malignancies, potentially influencing cell proliferation and metastasis. Additionally, its interaction with viral proteins highlights a role in host-pathogen interactions. Recombinant CCDC42A is often produced for functional studies using bacterial or mammalian expression systems, enabling structural analysis and mechanistic exploration. Despite its established roles, many aspects of its regulation, signaling partners, and disease-related pathways remain under investigation, making it a focus of cell biology and biomedical research.
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