| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CCDC121 |
| Uniprot No | Q6ZUS5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-278aa |
| 氨基酸序列 | MTDLNKHIKQAQTQRKQLLEESRELHREKLLVQAENRFFLEYLTNKTEEYTEQPEKVWNSYLQKSGEIERRRQESASRYAEQISVLKTALLQKENIQSSLKRKLQAMRDIAILKEKQEKEIQTLQEETKKVQAETASKTREVQAQLLQEKRLLEKQLSEPDRRLLGKRKRRELNMKAQALKLAAKRFIFEYSCGINRENQQFKKELLQLIEQAQKLTATQSHLENRKQQLQQEQWYLESLIQARQRLQGSHNQCLNRQDVPKTTPSLPQGTKSRINPK |
| 分子量 | 59.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **重组人卷曲螺旋结构域含蛋白121(CCDC121)** 的3条参考文献示例(注：以下内容为虚构示例，仅供参考。实际文献请通过PubMed或Google Scholar等数据库查询)：
1. **文献名称**：*"Characterization of CCDC121 as a Novel Coiled-Coil Domain Protein Involved in Cytoskeletal Organization"*
**作者**：Smith A, et al.
**摘要**：该研究通过免疫荧光和基因敲除实验，发现CCDC121在哺乳动物细胞中与微管网络相互作用，调节细胞形态和迁移能力，提示其在细胞骨架动态中的关键作用。
2. **文献名称**：*"CCDC121 Deficiency Disrupts Spermatogenesis via Impairing Sperm Flagella Formation in Mice"*
**作者**：Li X, et al.
**摘要**：在雄性小鼠模型中，CCDC121的缺失导致精子鞭毛结构异常和运动缺陷，表明其在精子形成过程中对纤毛/鞭毛组装至关重要，可能与男性不育相关。
3. **文献名称**：*"Genomic Analysis Links CCDC121 to Autophagy Pathways in Cancer Cell Survival"*
**作者**：Wang Y, et al.
**摘要**：通过CRISPR筛选和蛋白质组学，发现CCDC121通过与自噬相关蛋白LC3B的互作促进肿瘤细胞在营养应激下的存活，揭示其潜在的促癌机制。
4. **文献名称**：*"CCDC121 Expression Profile and Evolutionary Conservation Across Vertebrates"*
**作者**：Kim H, et al.
**摘要**：研究分析了CCDC121在多种脊椎动物中的进化保守性，并通过单细胞测序发现其高表达于发育中的神经嵴细胞，提示其在胚胎发育中的潜在功能。
如需真实文献，建议使用关键词 **"CCDC121"** 在学术数据库(如PubMed、Web of Science)中检索，或参考相关领域综述文章。
Coiled-coil domain-containing protein 121 (CCDC121) is a human protein encoded by the *CCDC121* gene, located on chromosome 2p23.3. It belongs to the family of coiled-coil domain-containing proteins, which are characterized by their α-helical coiled-coil motifs. These structural domains mediate protein-protein interactions, oligomerization, and subcellular localization, suggesting CCDC121 may play roles in cellular organization or signaling. While functional studies on CCDC121 remain limited, bioinformatic analyses indicate its potential involvement in ciliogenesis, intracellular transport, or cytoskeletal regulation. It shares homology with other cilia-associated proteins, implying a possible link to ciliopathies—genetic disorders arising from defective cilia. CCDC121 expression has been detected in various tissues, including testis, brain, and respiratory epithelia, hinting at tissue-specific roles. Current research focuses on elucidating its interactome and structural properties. Some studies propose its interaction with microtubule-associated proteins, supporting a role in cellular trafficking or mitosis. However, mechanistic details and disease associations remain speculative. Further investigations using knockdown models or cryo-EM could clarify its physiological functions and therapeutic relevance in ciliopathies or cancer.
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