| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C9orf39 |
| Uniprot No | Q9NXG0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1405aa |
| 氨基酸序列 | MAARSPPSPHPSPPARQLGPRSPRVGRGAEVHAMRSEASGFAGAAREVVADESDKIWVGEEGSGGRRGPGGAAPAHAPLLSAPMGSRRLEGISVEEAMVTRTQLLEEELSSLKEELALCQADKEFVWSLWKRLQVTNPDLTQVVSLVVEREKQKSEAKDRKVLEILQVKDAKIQEFEQRESVLKQEINDLVKRKIAVDEENAFLRKEFSDLEKKFKDKSQEIKDTKECVQNKEEQNRLVIKNLEEENKKLSTRCTDLLNDLEKLRKQEAHLRKEKYSTDAKIKTFEDNLIEARKEVEVSQSKYNALSLQLSNKQTELIQKDMDITLVRKELQELQNLYKQNSTHTAQQAELIQQLQVLNMDTQKVLRNQEDVHTAESISYQKLYNELHICFETTKSNEAMLRQSVTNLQDQLLQKEQENAKLKEKLQESQGAPLPLPQESDPDYSAQVPHRPSLSSLETLMVSQKSEIEYLQEKLKIANEKLSENISANKGFSRKSIMTSAEGKHKEPPVKRSRSLSPKSSFTDSEELQKLRKAERKIENLEKALQLKSQENDELRDAHEKRKERLQMLQTNYRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKMNLEEELDELKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQTLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKELEQIIKGSKDVEKENTELQVKISELETEVTSLRRQVAEANALRNENEELINPMEKSHQSADRAKSEMATMKVRSGRYDCKTTMTKVKFKAAKKNCSVGRHHTVLNHSIKVMSNVFENLSKDGWEDVSESSSDSEAQTSQTLGTIIVETSQKISPTEDGKDQKESDPTEDSQTQGKEIVQTYLNIDGKTPKDYFHDKNAKKPTFQKKNCKMQKSSHTAVPTRVNREKYKNITAQKSSSNIILLRERIISLQQQNSVLQNAKKTAELSVKEYKEVNEKLLHQQQVSDQRFQTSRQTIKKLNLDLAGLRKEKEDLLKKLESSSEITSLAEENSQVTFPRIQVTSLSPSRSMDLEMKQLQYKLKNATNELTKQSSNVKTLKFELLAKEEHIKEMHEKISRMERDITMKRHLIEDLKFRQKVNLESNKSFSEMLQNLDKKVKTLTEECSNKKVSIDSLKQRLNVAVKEKSQYEQMYQKSKEELEKKDLKLTLLVSRISETESAMAEIETAASKQLQELALQSEQVLEGAQKTLLLANEKVEEFTTFVKALAKELQNDVHVVRRQIRELKKMKKNRDACKTSTHKAQTLAASILNISRSDLEEILDTEDQVEIEKTKIDAENDKEWMLYIQKLLEGQSLTLSPRLKCNGAIVAHQNLRLPDSSSSASAS |
| 分子量 | 161 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C9orf39蛋白的示例参考文献(内容基于假设性研究，仅供参考)：
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1. **文献名称**：*Molecular Cloning and Functional Characterization of C9orf39 in Cell Proliferation*
**作者**：Zhang L, Wang Y, et al.
**摘要**：本研究首次报道了通过重组技术表达人C9orf39蛋白，并发现其在HeLa细胞中过表达可显著抑制细胞周期进程。实验表明C9orf39通过调控CDK2/cyclin E复合物影响G1/S期转换，提示其在细胞增殖中的潜在作用。
2. **文献名称**：*Structural Analysis of Recombinant Human C9orf39 Using Cryo-EM*
**作者**：Chen X, Liu H, et al.
**摘要**：利用冷冻电镜技术解析了重组人C9orf39蛋白的3.2 Å分辨率结构，揭示了其独特的α-螺旋结构域和可能的核酸结合位点，为研究其参与DNA修复的分子机制提供了结构基础。
3. **文献名称**：*C9orf39 Expression Correlates with Poor Prognosis in Glioblastoma*
**作者**：Kim S, Patel R, et al.
**摘要**：通过免疫组化分析发现，C9orf39在胶质母细胞瘤组织中高表达，且与患者生存期缩短相关。体外实验证实，重组C9orf39蛋白可通过激活MAPK通路促进肿瘤细胞侵袭。
4. **文献名称**：*Interaction Network of Recombinant C9orf39 in Stress Granule Formation*
**作者**：Gupta M, Tanaka T, et al.
**摘要**：研究发现，重组人C9orf39蛋白在氧化应激条件下与TIA-1、G3BP1等应激颗粒标志物共定位，并参与调控应激颗粒的组装，提示其在细胞应激反应中的新功能。
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**注意**：上述文献为模拟内容，实际研究中可能需通过PubMed、Web of Science等平台以“C9orf39”或“Chromosome 9 open reading frame 39”为关键词检索真实论文。
Here’s a concise overview of the recombinant human C9orf39 protein:
The C9orf39 protein, encoded by the *C9orf39* gene (Chromosome 9 Open Reading Frame 39), is a poorly characterized protein with limited functional annotations. It is evolutionarily conserved across mammals but lacks definitive domain motifs, making its molecular role challenging to decipher. Current UniProt entries describe it as a small protein (~20 kDa) with putative nuclear localization signals, though subcellular localization studies remain inconclusive. Interest in recombinant C9orf39 stems from genomic studies linking its gene locus to neurological disorders and cancer susceptibility. While no direct disease associations are confirmed, altered *C9orf39* expression has been observed in glioblastoma and pancreatic adenocarcinoma tissues. Recombinant versions (often His-tagged or GFP-fused) are primarily used for antibody production, protein interaction assays, and subcellular tracking in vitro. Recent phosphoproteomic studies suggest potential roles in cell cycle regulation, though validation is ongoing. Its low abundance in native tissues necessitates recombinant systems (E. coli or mammalian cells) for biochemical studies. Further characterization of this orphan protein could clarify its involvement in stress response pathways hinted by co-expression networks.
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