| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C8orf46 |
| Uniprot No | Q8TAG6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-206aa |
| 氨基酸序列 | MHQIYSCSDENIEVFTTVIPSKVSSPARRRAKSSQHLLTKNVVIESDLYTHQPLELLPHRGDRRDPGDRRRFGRLQTARPPTAHPAKASARPVGISEPKTSNLCGNRAYGKSLIPPVPRISVKTSASASLEATAMGTEKGAVLMRGSRHLKKMTEEYPALPQGAEASLPLTGSASCGVPGILRKMWTRHKKKSEYVGATNSAFEAD |
| 分子量 | 48.9 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C8orf46** 的 **虚构参考文献示例**，因实际研究可能有限，以下内容仅供格式参考：
1. **Title**: *Bioinformatic Characterization of Human C8orf46: Insights into Structural and Functional Potential*
**Authors**: Johnson A, et al.
**Summary**: 通过生物信息学预测C8orf46的蛋白质结构，发现其具有保守的α-螺旋结构域和可能的酶活性位点，提示其参与细胞代谢调控。
2. **Title**: *Recombinant Expression and Subcellular Localization of C8orf46 in Cancer Cell Lines*
**Authors**: Chen L, et al.
**Summary**: 在HeLa细胞中成功重组表达C8orf46.免疫荧光显示其定位于细胞核周区域，可能与染色质重塑或转录调节相关。
3. **Title**: *C8orf46 as a Potential Biomarker in Neurodegenerative Disorders: A Transcriptome-Wide Association Study*
**Authors**: Müller T, et al.
**Summary**: 转录组关联分析发现C8orf46在阿尔茨海默病患者脑组织中表达异常，暗示其可能参与神经退行性病变机制。
4. **Title**: *Protein Interaction Network Analysis Reveals C8orf46 as a Novel Component of the MAPK Signaling Pathway*
**Authors**: Park S, et al.
**Summary**: 通过酵母双杂交筛选发现C8orf46与MAPK信号通路成员相互作用，可能调节细胞应激反应。
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**备注**：
- C8orf46目前研究较少，上述文献为虚构，真实文献建议查询 **PubMed**、**UniProt**(ID: Q6ZVM7)或 **Google Scholar** 获取最新进展。
- 可关注与染色体8p21区域相关的疾病研究或蛋白组学数据库(如STRING)获取间接线索。
C8orf46 (chromosome 8 open reading frame 46) is a poorly characterized human protein encoded by the *C8orf46* gene located on chromosome 8p23.1. Despite being conserved across vertebrates, its biological function remains largely unknown due to limited experimental validation. Bioinformatic analyses suggest it is a small protein (~12-15 kDa) with potential alpha-helical domains and possible intracellular localization. Sequence-based predictions indicate weak homology to proteins involved in lipid metabolism, though this remains unverified.
Expression profiling reveals *C8orf46* mRNA is broadly expressed in tissues, with higher levels in reproductive organs (testis, ovary) and glandular tissues, hinting at potential roles in cellular regulation or secretory processes. A few studies link its dysregulation to pathologies, including altered expression in hepatocellular carcinoma and endometriosis, but causal relationships are unconfirmed.
Recombinant C8orf46 is primarily generated for antibody production or structural studies, as its uncharacterized status limits functional assays. Current research gaps include unclear interactions, post-translational modifications, and pathway associations. CRISPR screens suggest it may influence cell proliferation under stress, but mechanistic insights are absent. Further studies—crystallography, interactome mapping, or conditional knockout models—are needed to define its role in physiology or disease. Its classification as a "missing protein" in proteomic databases underscores the need for deeper exploration.
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