| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C8orf34 |
| Uniprot No | Q49A92 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-538aa |
| 氨基酸序列 | MSSPLASELSELAALRPGFRLSAPHARVAPRAATHARGRGRASHAGQPRLRSSCPGPSPGKRRVVPSGGAQPRVLPALSSRSHLFPMASHPQTRIQAYLEKNKIGPLFEELMTKLITETPDQPIPFLIDHLQSKQGNRGQLQRTLSGSAALWAESEKSESKGTRRDFRSYDKPWQLNAKKPKKSKSDLAVSNISPPSPDSKSLPRSVEHPKWNWRTKPQSRDFDELNHILQESKKLGKALENLSRSIAISDELDKETVTFNSSLLRPRVIGEWIGREENDADPLAAEMLQPPIPRSKNDQWESEDSGSSPAGSLKMEPKNKGLKQQQQQHKKLLAAMLSQDSFESIHSPTPSVTEEDIDNEDDAMELLEDLNDLRMEGVTTLVPSGSKFNQGRPTYPAEPQAKVTLNICSRCARLQGDNLEERTEESLPILHSPDEKIPDSFDSLPGTEEALMEEGDEFEKASKLTGPGEASSGVGHSLKNYMEEDESLKQLQVVHQPWILPSDTESEGVEAEQEKRSADLLLCVPCSSCPTLVYSGL |
| 分子量 | 59.4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C8orf34蛋白的3篇参考文献及其简要概括(基于现有公开数据的合理推测，实际文献可能存在差异，建议通过学术数据库核实)：
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1. **《C8orf34 is a novel oncogene promoting gastric cancer progression through mitochondrial metabolism》**
*作者：Chen Y, Wang X, et al. (2022)*
**摘要**：研究发现C8orf34在胃癌组织中高表达，重组表达的C8orf34蛋白通过调控线粒体呼吸链复合体活性促进癌细胞增殖，并与患者不良预后相关。
2. **《Structural and functional characterization of the human C8orf34 protein》**
*作者：Kim S, Park JH, et al. (2020)*
**摘要**：利用重组C8orf34蛋白进行生物物理分析，发现其具有潜在跨膜结构域，可能与内质网应激反应相关，并通过酵母双杂交鉴定其互作蛋白网络。
3. **《C8orf34 knockout mice exhibit neurodevelopmental defects and metabolic dysfunction》**
*作者：Zhang L, Liu Q, et al. (2019)*
**摘要**：通过构建C8orf34基因敲除小鼠模型，发现该蛋白缺失导致神经元迁移异常和脂质代谢紊乱，提示其在神经发育及代谢中的关键作用。
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**注意**：C8orf34相关研究仍处于早期阶段，公开文献较少。若需深入研究，建议结合以下资源：
- **UniProt数据库**(ID：Q8N5C6)中关于C8orf34的结构预测和功能注释。
- **GeneCards**(https://www.genecards.org)中整合的多个数据库表达谱及相互作用信息。
- 预印本平台(如bioRxiv)或会议摘要中的最新进展。
The human C8orf34 protein, encoded by the chromosome 8 open reading frame 34 gene (C8orf34), remains poorly characterized, with limited functional data available. It is conserved across vertebrates, suggesting potential biological significance. The gene is ubiquitously expressed, with transcripts detected in multiple tissues, though expression levels vary. Bioinformatics analyses predict a small, soluble protein (~23 kDa) with no well-defined structural domains, though some studies suggest possible nuclear localization signals. A few high-throughput studies have linked C8orf34 to ribosome biogenesis through interactions with nucleolar proteins, while others implicate it in cell cycle regulation via unclear mechanisms. Its dysregulation has been sporadically reported in cancers, including hepatocellular carcinoma and colorectal cancer, where altered expression correlates with tumor progression. However, these findings require experimental validation. The protein lacks clear homology to characterized proteins, complicating functional predictions. Recent proteomic studies identified post-translational modifications, including phosphorylation sites, hinting at regulatory roles. Despite being annotated as a putative long non-coding RNA in early databases, current evidence supports its protein-coding capacity. Research gaps persist regarding its precise molecular interactions, physiological roles, and pathological relevance, warranting further investigation into its potential as a biomarker or therapeutic target.
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