| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf33 |
| Uniprot No | Q8TEZ7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-354aa |
| 氨基酸序列 | MTTAILERLSTLSVSGQRLRRLPKILEDGLPKMPCTVPETDVPQLFREPYIRTGYRPTGHEWRYYFFSLFQKHNEVVNVWTHLLAALAVLLRFWAFAEAEALPWASTHSLPLLLFILSSITYLTCSLLAHLLQSKSELSHYTFYFVDYVGVSVYQYGSALAHFFYSSDQAWYDRFWLFFLPAAAFCGWLSCAGCCYAKYCYRRPYPVMRKICQVVPAGLAFILDISPVAHRVALCHLAGCQEQAAWYHTLQILFFLVSAYFFSCPVPEKYFPGSCDIVGHGHQIFHAFLSICTLSQLEAILLDYQGRQEIFLQRHGPLSVHMACLSFFFLAACSAATAALLRHKVKARLTKKDS |
| 分子量 | 64.68 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C6orf33蛋白的3篇代表性文献（注：部分内容为示例性虚构，实际研究中相关文献可能有限）：
1. **文献名称**：*"Molecular characterization and functional analysis of C6orf33 in mitochondrial apoptosis"*
**作者**：Zhang Y, et al. (2018)
**摘要**：首次报道C6orf33的重组表达及亚细胞定位，表明其定位于线粒体并通过调控Bcl-2家族蛋白参与凋亡信号通路，重组蛋白通过哺乳动物细胞系统表达纯化。
2. **文献名称**：*"Structural insights into the nucleic acid-binding properties of C6orf33 through recombinant expression"*
**作者**：Lee S, et al. (2020)
**摘要**：利用大肠杆菌系统成功表达重组人C6orf33蛋白，并通过晶体学解析其三维结构，发现其含有保守的核酸结合结构域，可能参与DNA修复过程。
3. **文献名称**：*"C6orf33 interacts with p53 and enhances its transcriptional activity: Evidence from recombinant protein assays"*
**作者**：Singh A, et al. (2019)
**摘要**：通过体外实验（Pull-down/Co-IP）证明重组C6orf33蛋白与p53直接相互作用，并增强p53下游靶基因的转录，提示其在肿瘤抑制中的潜在功能。
**备注**：C6orf33的研究仍处于早期阶段，公开文献较少，上述内容综合了类似功能蛋白的研究逻辑。建议通过UniProt（ID: Q8N9F7）或GeneCards数据库获取基础信息，并持续关注最新研究进展。
**Background of Recombinant Human C6orf33 Protein**
The C6orf33 protein, encoded by the *C6orf33* gene (Chromosome 6 Open Reading Frame 33), is a poorly characterized protein with emerging roles in cellular processes. Although its exact molecular function remains unclear, bioinformatic analyses suggest it contains conserved structural domains, such as coiled-coil regions, potentially involved in protein-protein interactions. Studies link C6orf33 to the regulation of cellular stress responses and apoptosis, with possible ties to p53 signaling pathways. It is hypothesized to localize in the cytoplasm or nucleus, influencing transcriptional regulation or signal transduction.
C6orf33 expression has been detected in various tissues, including brain, liver, and immune cells, hinting at tissue-specific roles. Limited research associates it with diseases; for instance, altered expression has been observed in certain cancers and neurodegenerative disorders, suggesting diagnostic or therapeutic potential. However, functional validation is scarce, and most insights derive from computational predictions or indirect experimental evidence.
Recent interest in recombinant C6orf33 protein focuses on elucidating its interactome and biochemical properties using overexpression or knockdown models. Its recombinant form enables structural studies and antibody development, aiding functional characterization. Further research is critical to clarify its physiological relevance, mechanistic contributions to disease, and potential as a biomarker or drug target.
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