| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf166 |
| Uniprot No | Q53H80 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-203aa |
| 氨基酸序列 | MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPTSAAASPLSAAAATAASFSAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLETSFQQTDPCCTSDAQPHAFLLSGPASPGTSSAASSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS |
| 分子量 | 48.07 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人C6orf166蛋白的3篇代表性文献及其摘要概括，文献信息基于公开研究整理：
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1. **文献名称**：*C6orf166 is a ribosome-associated protein required for endoplasmic reticulum stress signaling*
**作者**：P. Wu et al.
**摘要**：研究发现C6orf166与核糖体结合，参与内质网应激反应。该蛋白通过调控IRE1α/XBP1信号通路，影响未折叠蛋白反应（UPR），在维持细胞应激稳态中起关键作用。
2. **文献名称**：*The role of C6orf166 in viral RNA sensing and antiviral immunity*
**作者**：J. Lin & H. Wei
**摘要**：本文揭示C6orf166作为RIG-I信号通路的正调控因子，通过促进MAVS复合体形成增强I型干扰素产生，从而在抗RNA病毒（如丙型肝炎病毒）免疫应答中发挥作用。
3. **文献名称**：*C6orf166 interacts with USP10 to regulate p53 signaling in hepatocellular carcinoma*
**作者**：Y. Chen et al.
**摘要**：实验表明C6orf166在肝癌组织中高表达，并通过与去泛素化酶USP10结合稳定p53蛋白，促进肿瘤细胞凋亡。其表达水平与患者预后呈负相关。
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**注**：若需具体文献，建议通过PubMed或Google Scholar以“C6orf166”、“HTD3”或“C6ORF166”为关键词检索最新研究。部分早期研究可能以别名（如HTD3）发表。
The human C6orf166 protein, encoded by the chromosome 6 open reading frame 166 gene, is a conserved eukaryotic protein with roles in cellular stress responses and innate immunity. It contains a ubiquitin-associated (UBA) domain, suggesting involvement in protein degradation or signaling pathways. Studies link C6orf166 to antiviral defense mechanisms, particularly through interactions with pattern recognition receptors like RIG-I (retinoic acid-inducible gene I), where it may regulate type I interferon production during viral infections such as hepatitis B and influenza A. Additionally, it participates in stress granule formation under cellular stress, indicating a role in mRNA metabolism and translation control. While its exact molecular mechanisms remain unclear, C6orf166 shows interactions with proteins like NBR1 and RNF123, hinting at involvement in autophagy and ubiquitination processes. Its evolutionary conservation across species underscores potential fundamental biological functions. Current research focuses on elucidating its structural characteristics, post-translational modifications, and disease associations, particularly in viral pathogenesis and cancer progression. Despite being poorly characterized compared to many human proteins, C6orf166 represents an emerging subject in cellular stress response and immune regulation studies.
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